Jean Claude TCHOUANKEU

Eschweilenol C and subfractions from Terminalia plants disrupt haemoglobin metabolism, inhibiting Plasmodium falciparum growth at rings and trophozoite stages

Mariscal Brice Tchatat Tali, Cedric Derick Jiatsa Mbouna, Aafreen Zehra, Steven Collins Njonté Wouamba, Guy Paulin Kemayou Mouthe, Aubin Youbi Kamche and 6 more

Malaria Journal

The rising prevalence of artemisinin-resistant malaria parasites in Africa underscores the urgent demand for new and effective therapeutic options. Historically, natural products have demonstrated significant anti- Plasmodium efficacy, indicating their potential as a source for malaria drug discovery. Extracts and fractions from Terminalia ivorensis and Terminalia brownii previously exhibited promising anti- Plasmodium potency; however, a thorough assessment of their pharmacodynamics across all asexual blood stages of Plasmodium falciparum and elucidation of their mode of action remains to be conducted. Products from the active fractions of T. ivorensis (Ti W Ea) and T. brownii (Tb M MeOH:Ea) were investigated throughout the asexual-blood and sexual stages of P. falciparum , focusing on their mechanism of inhibition and interaction with some key targets of haemoglobin metabolism. Both active fractions (Ti W Ea and Tb M MeOH:Ea) were fractionated by column chromatography, and the chemical structures of the isolated compound were elucidated through physical and spectroscopic techniques. The resulting compound and subfractions were screened in vitro against P. falciparum strains (Dd2, 3D7, and Dd2-GNF156), stage V gametocytes, and mammalian cells. The pharmacodynamics (stage-specific analysis and killing kinetics) of potent inhibitors were assessed and complemented by the effect on haemozoin formation. The molecular interaction between the potent compound and the two target enzymes was investigated through molecular docking. The fractionation of Ti W Ea yielded five subfractions (Ti01, Ti02, Ti03, Ti04, Ti05), while Tb M MeOH:Ea yielded three subfractions (Tb01, Tb02, Tb03) along with one compound (01) characterized as eschweilenol C. All Subfractions demonstrated good activity on susceptible and multidrug-resistant strains of P. falciparum (3D7 and Dd2) with an IC 50 ranging from 0.15 to 5.73 µg/ml. eschweilenol C equally displayed an IC 50 of 490.74 and 379.20 nM, respectively, on Pf Dd2 and Pf 3D7. Two top hits subfractions (Ti03; Ti04) from Ti W Ea and eschweilenol C from TbMMeOH:Ea exhibited a perfect antiplasmodial profile (IC 50 < 1 µg/ml); good selectivity (SI > 10) and demonstrated no spontaneous loss of efficacy when tested against mutant resistant strain ( Pf Dd2-GNF156) of P. falciparum . Ti03, Ti04, and eschweilenol C reduced haemozoin production, exhibited killing activity on ring and trophozoite stages and showed significant binding affinity to Pf M1AAP and Pf M17LAP. This study identifies eschweilenol C as a promising candidate for malaria drug discovery efforts and its significance for further exploration in the context of the emergence of artemisinin-resistant parasites in Africa.

• #malaria research and control
• #plant biochemistry and biosynthesis
• #phytochemicals and medicinal plants
• #plasmodium falciparum

Natural products as transmission-blocking agents against malaria: a comprehensive review of bioactive compounds and their therapeutic potential

Patrick Valère Tsouh Fokou, Mariscal Brice Tchatat Tali, Cedric Derick Jiatsa Mbouna, Lauve Rachel Tchokouaha Yamthé, Javad Sharifi‐Rad, Daniela Călina and 4 more

Malaria Journal

Malaria eradication is hindered by the persistence of transmission stages of Plasmodium falciparum that enable parasite transfer from humans to mosquitoes. Current therapeutic strategies, such as artemisinin-based combination therapy (ACT) combined with primaquine, are insufficient due to limited efficacy on mature gametocytes and safety concerns in populations with glucose-6-phosphate dehydrogenase deficiency. This highlights the critical need for innovative, safe, and effective transmission-blocking interventions. This review explores the potential of natural sources, including medicinal plants, marine organisms, and microorganisms-as reservoirs of novel bioactive compounds with anti-malarial properties. A comprehensive literature search identified promising natural products with gametocytocidal and sporontocidal activity, validated through advanced bioassays. The review also evaluates various methodologies, such as colorimetric, microscopy, and flow cytometry assays, for assessing transmission-blocking efficacy. The findings emphasize the potent gametocytocidal effects of certain plant extracts, such as Azadirachta indica and Vernonia amygdalina, and microbial products, including ionophores and proteasome inhibitors. Despite promising in vitro and in vivo data, the transition of these compounds to clinical applications remains limited. Challenges include standardizing assays, addressing resistance to current therapies, and ensuring drug safety for endemic populations. The current review underscores the untapped potential of natural products as transmission-blocking agents and proposes a systematic, stage-specific screening cascade to identify and optimize these compounds. Addressing these gaps could significantly advance global malaria eradication efforts.

• #malaria research and control
• #insect pest control strategies
• #computational drug discovery methods
• #malaria

Unveiling the antimalarial properties of Terminalia ivorensis (A. Chev) stem bark aqueous extract: In vivo efficacy testing and in silico predictions

Mariscal Brice Tchatat Tali, Eugenie Aimée Madiesse Kemgne, Cedric Derick Jiatsa Mbouna, Marius Jaurès Tsakem Nangap, Aubin Youbi Kamche, Souleyman Hassan and 2 more

International Journal of Plant Based Pharmaceuticals

Due to the spreading resistance to antimalarial drugs, new therapeutics are urgently needed, preferably with novel modes of action. Extracts from Terminalia ivorensis have previously been shown to possess activity in vitro against multidrug-resistant and drug-sensitive strains of Plasmodium falciparum. However, to the best of our knowledge, no scientific study has been published describing the antimalarial potential of these extracts through in vivo efficacy testing. This study aimed to determine the safety and antimalarial efficacy of the T. ivorensis stem bark aqueous extract (TiH2O) in a mouse model using the OECD 423 protocol and the suppressive and curative murine malaria models, and to predict in silico the pharmacokinetic properties and drug-likeness of two major phytochemical constituents. The in vivo antimalarial efficacy was assessed using the P. berghei NK65-infected mice. The TiH2O treatment impact on biochemical parameters was measured using established standard procedures. The pharmacokinetics prediction was achieved through the pkCSM predictor and Swiss ADME. The TiH2O extract was nontoxic in BALB/c mice at a lethal dose of 50 (LD50) &gt; 2000 mg/kg. The TiH2O extract displayed strong antimalarial efficacy with 100% parasitemia suppression at 200 mg/kg b.w. after 4 days of treatment while its oral administration at 400 mg/kg b.w. in the curative model significantly decreased P. berghei parasitemia by 94.07% with a median efficacy dose (ED50) of 96.80 mg/kg. The administration of TiH2O extract restored the histological parameters disrupted by P. berghei, and the transaminase (ALT and AST) activity, creatinine, and bilirubin levels significantly decreased compared to the negative control mice. In silico explorations showed that the main constituents leucodelphidin (leucodelphinidin) and ellagic acid of the TiH2O extract have drug-like properties, thus indicating that T. ivorensis might constitute a promising source of antimalarial chemical entities with good pharmacokinetics and drug-like properties. The results obtained further corroborated the preliminary in vitro antiplasmodial studies of T. ivorensis stem bark aqueous extract. The metabolome of TiH2O extract should be further profiled in the prospects of characterizing novel natural product scaffolds to support antimalarial drug discovery.

• #phytochemicals and medicinal plants
• #computational drug discovery methods
• #diverse scientific research studies
• #in silico

CCDC 2205944: Experimental Crystal Structure Determination

Bel Youssouf G. Mountessou, Alain W. Ngouonpe, Alexis Sylvain W. Mbobda, Eric O. Akintemi, Hans‐Georg Stammler, Siméon F. Kouam and 5 more

The Cambridge Structural Database

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

• #crystallization and solubility studies
• #x-ray diffraction in crystallography
• #crystal structure
• #crystallography

Crystal Structure, Vibrational Spectroscopy, Dft Calculated Electronic Properties and Molecular Docking Study of Pachypodostyflavone: A Potent Anti-Onchocerca

Bel Youssouf G. Mountessou, Alain W. Ngouonpe, Hans‐Georg Stammler, Eric O. Akintemi, Alexis Sylvain W. Mbobda, Siméon F. Kouam and 5 more

SSRN Electronic Journal

• #synthesis of organic compounds
• #antioxidant activity and oxidative stress
• #synthesis and biological activity
• #spectroscopy

&lt;i&gt;In vivo&lt;/i&gt; antiplasmodial properties of fractions and flavonoids of &lt;i&gt;Pseudarthria hooheri&lt;/i&gt; Wight &amp; Arn. (Fabaceae)

Joseph Tchamgoue, Amelework Eyado, Boniface Pone Kamdem, Yvan Anderson T. Ngandjui, Jean Claude Tchouankeu, Siméon F. Kouam and 1 more

Natural Resources for Human Health

Malaria is regarded as one of the most lethal diseases. Resistance to artemisinin and its derivatives jeopardises effective malaria treatment. Finding novel antimalarial chemicals is critical given the existing treatment situation. This work aimed to examine the antiplasmodial capabilities of &lt;i&gt;Pseudarthria hookeri&lt;/i&gt; fractions and flavonoids in vivo. The fractions and compounds antiplasmodial activity were evaluated on male Swiss albino mice infected with &lt;i&gt;Plasmodium berghei&lt;/i&gt;, and on healthy female Swiss albino mice, the crude extract's acute toxicity was assessed. The EtOAc fraction had significant antiplasmodial activity (32.53 percent suppression at 500 mg/kg BW) and considerably prolonged the survival period of infected mice (9.8 days) compared to control mice (7.8 days). Parasitaemia was dramatically reduced (85.01, 59.41, and 70.39 percent), and the mean survival time extended (11.33, 10.00, and 9.33 days) with 15, 20 and 35 mg/kg of quercetin (&lt;b&gt;1&lt;/b&gt;), 7-O-benzyl-6-prenylpinocembrin (&lt;b&gt;6&lt;/b&gt;) and 6,8-diprenyleriodictyol (&lt;b&gt;11&lt;/b&gt;) (isolates of the EtOAc fraction), respectively. BW loss and PCV reduction were also averted. Moreover, at 2500 mg/kg, the crude extract of &lt;i&gt;P. hookeri&lt;/i&gt; showed no acute toxicity in mice. LC-MS analysis of the EtOAc fraction enabled the identification of nine flavonoids, with &lt;b&gt;8&lt;/b&gt; and &lt;b&gt;11&lt;/b&gt; being the main components. The present investigation confirmed &lt;i&gt;P. hookeri&lt;/i&gt;'s antiplasmodial action, substantiating its ethnomedicinal application for malaria treatment.

• #malaria research and control
• #pharmacological effects of natural compounds
• #ethnobotanical and medicinal plants studies
• #in vivo

A new dibenzofuran derivative from the stem bark of Scyphocephalium ochocoa with anti-inflammatory and cytotoxic activities

Guy Raymond Feuya Tchouya, Hibrahim Foundikou, Marius Mbiantcha, Jean Jules Bankeu Kezetas, Jean‐Bernard Bongui, Jean Claude Tchouankeu and 2 more

Natural Product Research

The phytochemical investigation of the dichloromethane/methanol (1:1) extract of the stem bark of Scyphocephalium ochocoa, led to the isolation of one new dibenzofuran derivative, named scyphocephalione A (1), along with three other compounds, including epicatechin (2), gentisic acid (3) and myo-inositol (4). The structures of all the compounds were established with help of spectroscopic data including IR, UV, MS, 1 D- and 2 D-NMR, as well as by comparison with previously reported data in literature, and chemical modification. All the compounds were obtained from the genus Scyphocephalium for the first time. The anti-inflammatory activity (using chemiluminescence technique) of the crude extract and compound 1, together with NO inhibition (using ELISA), TNF-α (using ELISA) and MCF-7 cells cytotoxicity effects (using MTT assay) of compound 1 were assessed. From the results obtained, compound 1 could be considered as a promising chemotherapeutic agent for the treatment of inflammatory diseases.

• #phytochemical compounds biological activities
• #natural product bioactivities and synthesis
• #synthesis of organic compounds
• #phytochemical

CCDC 1992702: Experimental Crystal Structure Determination

Gervais Mouthé Happi, Guy Paulin Mouthé Kemayou, Hans‐Georg Stammler, Beate Neumann, Mohamed Ismail, Siméon F. Kouam and 5 more

The Cambridge Structural Database

• #crystallization and solubility studies
• #x-ray diffraction in crystallography
• #crystal structure
• #crystallography

CCDC 1992703: Experimental Crystal Structure Determination

Gervais Mouthé Happi, Guy Paulin Mouthé Kemayou, Hans‐Georg Stammler, Beate Neumann, Mohamed Ismail, Siméon F. Kouam and 5 more

The Cambridge Structural Database

• #crystallization and solubility studies
• #x-ray diffraction in crystallography
• #crystal structure
• #crystallography

Constituents from Nauclea latifolia with Anti- Haemophilus influenzae Type b Inhibitory Activities

Jean Jules Kezetas Bankeu, Donald Ulrich Kenou Kagho, Yannick Stéphane Fotsing Fongang, Rufin Marie Kouipou Toghueo, Brice Mittérant Mba’ning, Guy Feuya and 6 more

Journal of Natural Products

Three previously undescribed indole alkaloids, named latifolianine A ( 1 ) and latifoliaindoles A and B ( 2 and 3 ), along with 10 known compounds ( 4 – 13 ), were isolated from the heartwood of Nauclea latifolia . Their structures were elucidated based on the analysis of their NMR and MS data. Latifolianine A ( 1 ) represents an unusual and unprecedented monoterpene indole alkaloid unit condensed with an ursane-type pentacyclic triterpenoid moiety. Plausible biogenetic routes toward latifolianine A ( 1 ) and latifoliaindoles A and B ( 2 and 3 ) were proposed. All the isolates were assessed in vitro for their inhibitory effects on Haemophilus influenzae . Naucleidinal ( 7 ) exhibited potent antibacterial activity (MIC value of 3.1 μg/mL) as compared to a reference drug, ciprofloxacin (MIC value of 1.6 μg/mL).

• #alkaloids: synthesis and pharmacology
• #traditional and medicinal uses of annonaceae
• #natural product bioactivities and synthesis
• #stereochemistry

Antibacterial activity and cytotoxicity of flavonoids compounds isolated from Pseudarthria hookeri Wight &amp; Arn. (Fabaceae)

Jean Paul Dzoyem, Joseph Tchamgoue, Jean Claude Tchouankeu, Siméon F. Kouam, M. Iqbal Choudhary, Udo Bakowsky

South African Journal of Botany

Pseudarthria hookeri is used in Africa for the treatment of pneumonia, cough, abdominal pains and diarrhea. However the bioactive constituents underlying the health benefits associated with P . hookeri remain unknown. In this study, the antibacterial activity and the cytotoxicity of compounds isolated from Pseudarthria hookeri were investigated. The antibacterial activity was assessed by determining the minimum inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) using the broth microdilution method and the antiproliferative effect against cancer cells was determined by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay. Compounds 1 and 4 showed the highest antibacterial effect with minimum inhibitory concentration (MIC) values ranging from 16 to 32 and 8 to 64 μg/mL, against Gram-positive and Gram negative bacteria, respectively. The same compounds induced a remarkable cytotoxic activity toward human T-Cell leukemia Jurkat cells with respective IC 50 values of 3.59 and 5.59 μg/mL. Our results suggest that flavonoids from P . hookeri exhibit significant antibacterial activity and antiproliferative effect on human cancer cell lines. These compounds might underlie the health benefits associated with the plant. Compounds 1 and 4 emerged as promising drug candidates, highlighting their potential as lead compounds.

• #bioactive natural compounds
• #ethnobotanical and medicinal plants studies
• #phytochemistry and biological activities
• #antibacterial activity

Flavonoids and other constituents with insulin secretion activity from Pseudarthria hookeri

Joseph Tchamgoue, Rahman M. Hafizur, Jean Claude Tchouankeu, Siméon F. Kouam, Achyut Adhikari, Abdul Hameed and 2 more

Phytochemistry Letters

• #bioactive natural compounds
• #natural antidiabetic agents studies
• #biological and pharmacological studies of plants
• #protocatechuic acid

Ethnopharmacological surveys and pharmacological studies of plants used in traditional medicine in the treatment of HIV/AIDS opportunistic diseases in Gabon

Guy Raymond Feuya Tchouya, Alain Souza, Jean Claude Tchouankeu, Jean-Fabrice Yala, Marlaine Boukandou Mounanga, Hibrahim Foundikou and 6 more

Journal of Ethnopharmacology

• #phytochemistry and bioactivity studies
• #ethnobotanical and medicinal plants studies
• #phytochemistry and bioactive compounds
• #traditional medicine

In Vitro Evaluation of Antimicrobial and Antiproliferative Activities for Compounds Isolated from the Ficus Bubu Warb. (Moraceae) Fruits: Chemotaxonomic Significance

Jean Mbosso, Louis Kamdem, Jules Nguedia, F. Meyer, Diane Ebelle, Bruno Ndjakou Lenta and 6 more

Drug Delivery Letters

This study investigated the in vitro antimicrobial and antiproliferative activities of the methanol extract and of purified compounds from fruits of Ficus bubu Warb. Extensive chromatographic isolations provided two stilbenes, that were identified by NMR and mass spectrometry as trans-resveratrol 4a and piceid 7a, in addition to several other chemical compounds. It was found that trans-resveratrol 4a exhibited the best antimicrobial activity (MIC value of 11 μg/mL), and presented a good anticancer activity (IC50 of 36 and 57 µM against A549 and SK-MEL-28 cancer cell lines, respectively). The peracetylation of isolated compounds was found to increase their antiproliferative activity. The peracetylated piceid 7b was the most efficient with an IC50 of 16 µM against the cells of melanoma skin cancer SK-MEL-28 while the starting crude extract did not show any activity. In contrast, this crude extract exhibited good antimicrobial activity against all tested strains. The present study constitutes the first phytochemical report on the methanol extract from F. bubu fruits and establishes the preliminary basis for its medical use. Finally, it is worth mentioning that polyphenolic piceid 7a is isolated for the first time from a plant of the genus Ficus. Keywords: Bioactivity, cancer, chemotaxonomy, Ficus bubu, piceid hexaacetate, piceid, trans-resveratrol triacetate, transresveratrol.

• #phytochemistry and biological activities of ficus species
• #phytochemical
• #antimicrobial
• #moraceae

ChemInform Abstract: Flavonoid Glycosides and Other Constituents of Psorospermum androsaemifolium Baker (Clusiaceae)

Hervé Martial Poumale Poumale, Rivoarison Randrianasolo, Jeannot Victor Rakotoarimanga, Amélie Raharisololalao, Hans Christoph Krebs, Jean Claude Tchouankeu and 1 more

ChemInform

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

• #bioactive natural compounds
• #phytochemistry and biological activities
• #traditional and medicinal uses of annonaceae
• #chemistry

ChemInform Abstract: Pentacyclic Triterpenes and Other Constituents from Ficus cordata (Moraceae).

Hervé Martial Poumale Poumale, Rodrigue T. Kengap, Jean Claude Tchouankeu, Félix Keumedjio, Hartmut Laatsch, Bonaventure T. Ngadjui

ChemInform

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

• #phytochemistry and biological activities
• #phytochemistry and biological activities of ficus species
• #natural product bioactivities and synthesis
• #moraceae

Flavonoid Glycosides and Other Constituents of Psorospermum androsaemifolium BAKER (Clusiaceae)

Hervé Martial Poumale Poumale, Rivoarison Randrianasolo, Jeannot Victor Rakotoarimanga, Amélie Raharisololalao, Hans Christoph Krebs, Jean Claude Tchouankeu and 1 more

Chemical and Pharmaceutical Bulletin

Two new flavonoid glycosides, namely 3'-(2'',4''-dihydroxybenzyloxy)acanthophorin B (1b) and beta,2,3',4,4',6-hexahydroxy-alpha-(alpha-L-rhamnopyranosyl)dihydrochalcone (2) were isolated from the leaves of Psorospermum androsaemifolium together with quercetin (1), acanthophorin B (1a), alpha- (3) and beta-amyrine (3a), vismiaquinone (4), 12-hentriacontanol and hentriacontane. The structures of these secondary metabolites were established using detailed spectroscopic analysis and by comparison with published data. Compounds 1, 1a, 1b, 2, 3, 3a and 4 showed weak antifungal and antibacterial activities.

• #phytochemistry and biological activities
• #natural product bioactivities and synthesis
• #bioactive natural compounds
• #clusiaceae

Pentacyclic Triterpenes and Other Constituents from Ficus cordata (Moraceae)

Hervé Martial Poumale Poumale, Rodrigue T. Kengap, Jean Claude Tchouankeu, Félix Keumedjio, Hartmut Laatsch, Bonaventure T. Ngadjui

Zeitschrift für Naturforschung B

Abstract Two new pentacyclic triterpenes 8,26-cyclo-urs-21-en-3β, 20β-diol (1) and 3β-acetoxy-8.26- cyclo-ursan-20β-ol (2) together with 3-friedelanone, oleanolic acid, betulinic acid, lupeol acetate, α- and β-amyrine, S.SJ^'-tetrahydroxyflavane, and 3,5,7,3',4'-pentahydroxyflavane were isolated from the stem bark of Ficus cordata (Moraceae). The structures of these secondary metabolites were established using ID and 2D NMR spectra and by comparison with published data or with authentic samples. Compounds 1 and 2 exhibited weak antibacterial and no antifungal activity.

• #phytochemistry and biological activities
• #natural product bioactivities and synthesis
• #plant biochemistry and biosynthesis
• #moraceae

&lt;i&gt;In Vitro &lt;/i&gt; anti-malarial activity of limonoids from two meliacious plants

Jean Bickii, Guy Raymond Feuya Tchouya, Jean Claude Tchouankeu, Etienne Tsamo

West African Journal of Pharmacology and Drug Research

Four limonoids, atomasin A 1, atomasin B 2, entilin A 3 and entilin B 4 from Entandrophragma candollei and Entandrophragma utile (Meliaceae) were tested for in vitro antimalarial activity against Plasmodium falciparum chloroquine–resistant W2 strain. Three limonoids (1, 3, 4) were moderately active with IC50 values between 11.6 and 28.2 µg/mL. atomasin B was devoid of activity. The in vitro activities of the compounds were further analysed using fresh isolates of P. falciparum among which three were chloroquine–resistant. The comparison of the mean IC50 values of atomasin A and entilin B did show any significant difference between chloroquine-resistant and –sensitive isolates. Keywords: Plasmodium falciparum; Antimalarial activity; Meliaceae; Limonoids; Entandrophragma candollei; Entandrophragma utile. West African Journal of Pharmacology and Drug Research Vol. 21 (1&2) 2005: pp. 39-42

• #phytochemical compounds biological activities
• #meliaceae
• #plasmodium falciparum
• #chloroquine

Antimalarial activity in crude extracts of some Cameroonian medicinal plants

Jean Bickii, GRF Tchouya, Jean Claude Tchouankeu, Etienne Tsamo

African Journal of Traditional Complementary and Alternative Medicines

Fifteen crude extracts from the stem bark and seeds of four medicinal plants, viz: Entandrophragma angolense, Picralima nitida, Schumanniophyton magnificum and Thomandersia hensii were tested in vitro for their antimalarial activity against the chloroquine-resistant Plasmodium falciparum W2 strain. The results showed that the extracts of these plants possessed some antimalarial activity, the methanol extract of Picralima nitida demonstrating the highest activity in vitro. Further isolation and identification of some active compounds from these plants will justify their common use in traditional medicine for the treatment of malaria or fever in Cameroon.Keywords: Entandrophragma angolense; Picralima nitida; Schumanniophyton magnificum; Thomandersia hensii; Plasmodium falciparum; Antimalarial activity The African Journal of Traditional, Complementary and Alternative Medicines Vol. 4 (1) 2007: pp. 107-111

• #malaria research and control
• #traditional and medicinal uses of annonaceae
• #insect pest control strategies
• #traditional medicine

&lt;b&gt;Meiocarpin: A novel lignan from the stem bark of &lt;i&gt;Meiocarpidium lepidotum&lt;/i&gt; (Annonaceae)&lt;/b&gt;

Silvère Augustin Ngouela, Guy Feuya, Jean Claude Tchouankeu, Gaston Achoundong, Raymond B.T. Zambou, Etienne Tsamo and 1 more

Bulletin of the Chemical Society of Ethiopia

A new lignan, meiocarpin, and the known compounds, sitosterol and polycarpol, have been isolated from the stem bark of Meiocarpidium lepidotum, Annonaceae. The structure of the new compound was elucidated on the basis of its spectroscopic data. KEY WORDS: Meiocarpidium lepidotum, Annonaceae, lignan Bull. Chem. Soc. Ethiop. 2004, 18(2), 221-224.

• #traditional and medicinal uses of annonaceae
• #african botany and ecology studies
• #phytochemistry and biological activities
• #annonaceae

Meiocarpin: A novel lignan from the stem bark of Meiocarpidium lepidotum (Annonaceae)

Silvère Augustin Ngouela, Guy Feuya, Jean Claude Tchouankeu, Gaston Achoundong, Raymond B.T. Zambou, Etienne Tsamo and 1 more

DOAJ (DOAJ: Directory of Open Access Journals)

A new lignan, meiocarpin, and the known compounds, sitosterol and polycarpol, have been isolated from the stem bark of <i>Meiocarpidium lepidotum</i>, Annonaceae. The structure of the new compound was elucidated on the basis of its spectroscopic data.

• #plant parasitism and resistance
• #traditional and medicinal uses of annonaceae
• #phytochemistry and biological activities
• #lignan

Entilins A and B, two novel heptanortriterpenoid derivatives from entandrophragma utile (meliaceae): Structural elucidation using 2d nmr long-range δC/δH correlation experiments

Jean Claude Tchouankeu, Etienne Tsamo, B.L. Sondengam, Joseph D. Connolly, David S. Rycroft

Tetrahedron Letters

• #natural product bioactivities and synthesis
• #microbial metabolites in food biotechnology
• #pharmacological effects of natural compounds
• #chemistry

Atomasins A and B, tetranortriterpenoids from the bark of Entandrophragma candollei

Jean Claude Tchouankeu, Etienne Tsamo, Beibam L. Sondengam, Joseph D. Connolly

Phytochemistry

• #traditional and medicinal uses of annonaceae
• #phytochemical compounds biological activities
• #agricultural pest management studies
• #bark (sound)