Scientific publications
Josette Linda Toussi Matchi
Other affiliations: Centre National de la Recherche Scientifique · Laboratoire de Chimie · Université de Strasbourg
* (Corresponding author)
Isabelle Kuhn
Other affiliations: Laboratoire de Chimie · Université de Strasbourg
Jérôme Boissier
Other affiliations: Université de Perpignan
Marc Nothisen
Other affiliations: Laboratoire de Chimie · Université de Strasbourg
Guilhem Chaubet
Other affiliations: Laboratoire de Chimie · Université de Strasbourg
Delphine Garnier
Other affiliations: Laboratoire de Chimie · Université de Strasbourg
Sylvain Ursuegui
Other affiliations: Laboratoire de Chimie · Université de Strasbourg
Alain Wagner
Other affiliations: Laboratoire de Chimie · Université de Strasbourg
Natural Product Research
A new alkaloid, manniindole 1, together with four known compounds: aristolactam AII 2, aristolactam BII 3, piperolactam D 4 and polycarpol 5 were isolated from the crude extract EtOH-H2O (8:2) of the roots of Anonidium mannii by chromatographic separation. The structure elucidation was performed on the basis of a spectroscopic analysis (IR, HRESI MS, 1D and 2D NMR) as well as a comparison of their spectral data with those reported in the literature. For the first time, the crude extract and those isolated compounds were evaluated for their anti-schistosomal activity against Schistosoma mansoni and for cytotoxicity activity against Huh7 and A549 cells. Furthermore, they were also tested in vitro on the recent characterized Schistosoma mansoni NAD+ catabolizing enzyme (SmNACE) for their impact on this enzyme which is localized on the outer surface of the adult parasite. Compound 2 displayed quite good worm killing capability, while 4 showed significant inhibition of SmNACE.
