CO
Chargé de Cours
Scientific activity
Researcher profile
Faculty researcher at the University of Yaoundé I. Grade: Chargé de Cours.
Scientific publications
Nathalie S. Jouwa Tameye, Carine Mvot Akak, Georges Bellier Tabekoueng, Pierre Mkounga, Gabin Thierry M. Bitchagno, Bruno Ndjakou Lenta and 2 more
Biochemical Systematics and Ecology
Nathalie S. Jouwa Tameye, Carine Mvot Akak, Gervais Mouthé Happi, Marcel Frese, Hans‐Georg Stammler, Beate Neumann and 3 more
Phytochemistry Letters
Hermann Marius Feumo Feusso, Jean de dieu Dongmo, Hermine Laure Maza Djomkam, Carine Mvot Akak, Mehreen Lateef, Ayaz Ahmed and 4 more
Natural Product Sciences
The chemical investigation of the methanolic crude extract of leaves of Diospyros iturensis gave us 15 known secondary metabolites identified as mixture of α-amyrenone (1) and β-amyrenone (2), β-amyrin (3), mixture of β-sitosterol (4) and stigmasterol (5), betulin (6), uvaol (7), betulinic acid (8), ursolic acid (9), corosolic acid (10), actinidic acid (11),11-O-p-hydroxybenzoylbergenin (12), bergenin (13) and mixture of stigmasterol glucoside (14) and β-sitosterol glucoside (15) respectively. The structures of secondary metabolites were elucidated with the help of NMR and mass spectral data and by comparison of their spectral data with literature. Among the fifteen isolated compounds, four compounds were identified for the first time in Diospyros genus. These included uvaol (7), corosolic acid (10), actinidic acid (11) and 11-O-p-hydroxybenzoylbergenin (12). Crude methanolic extract of leaves and four isolated compounds including betulin (6), betulinic acid (8), 11-O-phydroxybenzoylbergenin (12) and bergenin (13) were evaluated for their antiproliferative activity against two cancer cell lines CAL-27 and NCI-H460 by the MTT assay, antioxidant potential and inhibitory activity against the lipoxygenase and urease enzymes, respectively. The results indicated that the methanolic crude extract of leaves exhibited moderate antioxidant activity and was inactive against the two cancer cell lines. Betulin (6), 11-O-p-hydroxybenzoylbergenin (12) and bergenin (13) exhibited moderate antioxidant and lipoxygenase inhibition with IC50 = 65.8, 85.6, 82.5 μM and IC50 = 58.5, 95.2, 76.2 μM, respectively. Furthermore, 11-O-p-hydroxybenzoylbergenin (12) and bergenin (13) exhibited moderate urease inhibition activity with IC50 values of 45.6 μM and 49.8 μM, respectively.
Hermann Feumo Feusso, Jean de dieu Dongmo, Carine Mvot Akak, Mehreen Lateef, Ayaz Ahmed, Anatole Guy Blaise Azébazé and 3 more
Trends in Phytochemical Research
This study aimed for investigating chemical constituents and biological activities of Diospyros zenkeri (Gurke) F. White. 14 known secondary metabolites have been isolated from the leaves and the twigs of D. zenkeri such as 3-methoxy-7-methyljuglone (1), β-carotene (2), lupeol (3), mixture of β-sitosterol (4) and stigmasterol (5), betulin (6), ursolic acid (7), messagenin (8), 3β,28,30-lup-20(29)-ene triol (9), mixture of the glucosides of stigmasterol (10) and β-sitosterol (11), norbergenin (12), betulinic acid (13) and vanillic acid (14), respectively . The structures of the compounds were elucidated with the help of NMR and mass spectral studies. The compounds 8, 9 and 14 are reported for the first time from the genus Diospyros. The biological screening of all the isolates and the crude methanolic extracts have been carried out including antiproliferative activity, antioxidant potential and inhibitory activity against the enzymes lipoxygenase and urease, respectively. Compound 1 exhibited significant antiproliferative activity against two cancer cell lines CAL-27 (IC50=2.98 μM) and NCI-H460 (IC50=5.57 μM). Methanolic extracts of the leaves and twigs of D. zenkeri presented low antiproliferative activity against these two cancer cell lines. Compounds 1, 6, 8, 9, 12 and the crude extracts exhibited moderate antioxidant activity with IC50 values of 76.5 μM, 65.8 μM, 55.3 μM and 51.2 μM respectively compared to BHA (IC50=44.2 μM). Compounds 6, 8 and 9 showed moderate lipoxygenase inhibition activity with IC50 values of 58.5 μM, 52.8 μM and 58.8 μM, respectively compared to baicalein (IC50=22.6 μM).
Jean de dieu Dongmo, Carine Mvot Akak, Michel Feussi Tala, Philippe Belle Ebanda Kedi, Anatole Guy Blaise Azébazé, Juliette Cathérine Vardamides and 1 more
Zeitschrift für Naturforschung B
Abstract Phytochemical investigation of the stem bark of Diospyros longiflora yielded longiflorol ( 1 ), a new bergenin α - d -apioside, together with bergenin ( 2 ) and five known compounds: lupeol ( S1 ), betulin ( S2 ), betulinic acid ( S3 ), stigmasterol ( S4 ) and stigmasterol glucoside ( S5 ). Their structures were determined by one-dimensional (1D) and 2D nuclear magnetic resonance experiments along with electrospray ionization high-resolution mass spectrometry and extended density-functional theory calculations of chiroptical properties. Longiflorol ( 1 ) and bergenin ( 2 ) were evaluated for their DPPH (2,2-diphenyl-1-picrylhydrazyl) antioxidant activity, with the crude extract for comparison and ascorbic acid as standard. The results showed that the extract and 2 had good antioxidant activity, whereas 1 showed only moderate activity at high concentration (>2 mg mL −1 ).
Yannick Fouokeng, Carine Mvot Akak, Michel Feussi Tala, Anatole Guy Blaise Azébazé, Birger Dittrich, Juliette Cathérine Vardamides and 1 more
The Cambridge Structural Database
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Hermann Marius Feumo Feusso, Carine Mvot Akak, Michel Feussi Tala, Anatole Guy Blaise Azébazé, Juliette Cathérine Vardamides, Hartmut Laatsch
Biochemical Systematics and Ecology
Hermann Marius Feumo Feusso, Carine Mvot Akak, Michel Feussi Tala, Anatole Guy Blaise Azébazé, Nolé Tsabang, Juliette Cathérine Vardamides and 1 more
ChemInform
Hermann Marius Feumo Feusso, Carine Mvot Akak, Michel Feussi Tala, Anatole Guy Blaise Azébazé, Nolé Tsabang, Juliette Cathérine Vardamides and 1 more
Zeitschrift für Naturforschung B
Abstract A new cycloartane triterpenoid named conocarpol ( 1 ) was isolated from the stem bark of Diospyros conocarpa , together with the known compounds aridanin ( 2 ), lupeol ( 3 ), betulin ( 4 ), betulinic acid ( 5 ), stigmasterol ( 6 ), and stigmasterol 3- O - β - d -glucopyranoside ( 7 ). Their structures were established on the basis of 1D and 2D NMR spectroscopy as well as mass spectrometry. Aridanin ( 2 ) is reported for the first time in the family Ebenaceae, and conocarpol ( 1 ) represents the first cycloartane triterpene within this family.
Carine Mvot Akak, Augustin Ephrem Nkengfack, Pengfei Tu
Natural Product Communications
From the ethyl acetate extract of the stems of Diospyros crassiflora Hiern, three new norbergenin derivatives, 4,11-di-O-galloylnorbergenin (1), 3-O-galloylnorbergenin (2), and 4-O-(4'-hydroxy-3'-methoxybenzoyl)-norbergenin (3), were isolated along with ten known compounds (4-13). Their structures were established by mean of spectroscopic techniques namely 1- and 2-D NMR experiments, mass spectrometry and comparison with reported data. Isolates 1-9 were evaluated for their ability to protect PC12 cells against hydrogen peroxide induced injury. Compounds with a galloyl group in their structure were found to prevent toxicity induced by H2O2 in PC12 cells.
Jean Paul Dzoyem, Frederick Agem Kechia, Victor Kuete, Constant Anatole Pieme, Carine Mvot Akak, Jean Gustave Tangmouo and 1 more
Natural Product Research
In vitro biological activities including phytotoxic, antifungal activities as well as acute toxicity of the methanol extract, fractions and/or isolated compounds from the stem bark of Diospyros canaliculata were investigated. Well agar diffusion and macrodilution assays were used for investigating the antifungal activity. A phytotoxicity assay was performed against Lemna minor while an acute toxicity assay was performed in mice via oral administration. As a result, plumbagin (5-hydroxy-2-methyl-1,4-naphtoquinone) and two known pentacyclic triterpenes (lupeol and lupenone) were isolated from the extract. With regards the antifungal activities, the inhibition zones varied from 16.51 to 24.86 mm and from 20.50 to 25.10 mm for the extract and plumbagin, respectively. The minimum inhibitory concentrations of the extract and plumbagin ranged between 12.5-25 and 0.78-1.56 µg mL(-1), respectively. At 50 µg mL(-1), the hexane fraction showed phytotoxic activities similar to paraquat, the standard phytotoxic inhibitor. The extract was found to be non-toxic to mice after administration per os. Based on the current findings, we can conclude that this extract is non toxic, with significant phytotoxic and antifungal properties due to the presence of plumbagin.
Carine Mvot Akak, Céline Mbazoa Djama, Augustin Ephrem Nkengfack, Peng‐Fei Tu, Liandi Lei
Fitoterapia
Georges Bellier Tabekoueng, Carine Mvot Akak, Gervais Mouthé Happi, Moses K. Langat, Marcel Frese, Hans‐Georg Stammler and 8 more
Phytochemistry Letters
Georges Bellier Tabekoueng, Carine Mvot Akak, Moses K. Langat, Anatole Guy Blaise Azébazé, Alain François Kamdem Waffo, M. Iqbal Choudhary and 1 more
Zeitschrift für Naturforschung B
Abstract The phytochemical study of the roots, leaves and twigs of Penianthus camerounensis Dekker (Menispermaceae) has led to the isolation and the characterization of 20 compounds. A ceramide, camerounamide ( 1 ), and a furoclerodanediterpenoid, camerounin ( 2 ), have not been described previously, while the compounds xylopic acid ( 3 ), syringaresinol ( 4 ), iso -propylmethylcyclohexa-1,4-diol ( 5 ), 1-(28-hydroxyoctacosanoyl)glycerol ( 6 ), scoparone ( 7 ), friedelin ( 8 ), friedelanol ( 9 ) and betulinic acid ( 10 ) are being reported for the first time from the genus Penianthus alongside 10 known compounds ( 11–20 ). Chemical structures were determined using 1D- and 2D-NMR spectroscopy, MS and chemical analysis. Their chemotaxonomic importance is discussed.
Georges Bellier Tabekoueng, Carine Mvot Akak, Moses K. Langat, Anatole Guy Blaise Azébazé, Alain François Kamdem Waffo, Dulcie A. Mulholland and 1 more
Phytochemistry Letters
Charlie Kenmoe Djeukeu, Michel Feussi Tala, Carine Mvot Akak, Anatole Guy Blaise Azébazé, Alain Wafo, Jean Duplex Wansi and 2 more
Planta Medica International Open
Abstract A new highly oxidized tetranortriterpenoid, named mayombensin (1), was isolated from the twigs of Guarea mayombensis together with five known compounds and, further, two ceramides, 3,4-dimethyl-secotirucalla-4(28),7,24-trien-3,21-dioic acid (3), the glucosides of stigmasterol and β-sitosterol, and the respective aglyca. The structure of 1 was elucidated by detailed NMR analysis and confirmed as a novel azadirachtin homologue.
Yannick Fouokeng, Carine Mvot Akak, Michel Feussi Tala, Anatole Guy Blaise Azébazé, Birger Dittrich, Juliette Cathérine Vardamides and 1 more
Fitoterapia
Researcher profile
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