Norbergenin Derivatives from Diospyros crassiflora (Ebenaceae) (opens in a new tab)

Authors

University of Yaoundé I

Augustin Ephrem Nkengfack (Corresponding author)

University of Douala

Carine Mvot Akak (Corresponding author)

Peking University

Pengfei Tu

Natural Product Communications

Abstract

From the ethyl acetate extract of the stems of Diospyros crassiflora Hiern, three new norbergenin derivatives, 4,11-di-O-galloylnorbergenin (1), 3-O-galloylnorbergenin (2), and 4-O-(4'-hydroxy-3'-methoxybenzoyl)-norbergenin (3), were isolated along with ten known compounds (4-13). Their structures were established by mean of spectroscopic techniques namely 1- and 2-D NMR experiments, mass spectrometry and comparison with reported data. Isolates 1-9 were evaluated for their ability to protect PC12 cells against hydrogen peroxide induced injury. Compounds with a galloyl group in their structure were found to prevent toxicity induced by H2O2 in PC12 cells.

Peking University

Abstract

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