Moise Ondoh Agwara

CCDC 2155769: Experimental Crystal Structure Determination

Armel L. Mbani O., Evan F. Bonnand, Awawou G. Paboudam, Jacob P. Brannon, Kevyn D. Gardner-Ricossa, S. Chantal E. Stieber et 1 autre(s)

The Cambridge Structural Database

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

• #crystallization and solubility studies
• #x-ray diffraction in crystallography
• #crystallography
• #materials science

Hydrated magnesium (II) with H-bonded hexamethylenetetramine and co-ligands: synthesis, structural characterization, thermal decomposition, and hirshfeld surface analysis

Tambua Neville Milo, Che Dieudonné Tabong, Jean Hubert Nono, Donatus Bekindaka Eni, Divine Mbom Yufanyi‬, Moise Ondoh Agwara

Chemical Papers

• #lanthanide and transition metal complexes
• #thermal and kinetic analysis
• #inorganic chemistry and materials
• #hexamethylenetetramine

Synthesis, characterization and antimicrobial properties of Cobalt(III), Nickel(III), Copper(II) and Zinc(II) complexes with pyridine and thiocyanate

Seth Armand Abalintsina, Mariam Asseng Conde, Donatus Bekindaka Eni, Moise Ondoh Agwara

Scientific African

Mixed-ligand complexes of Co(III), Ni(III), Cu(II) and Zn(II) with pyridine and thiocyanate have been synthesized and characterized using elemental analysis, infrared and UV-Vis spectroscopy, thermal analytical techniques, melting point determination, molar conductivity and room temperature magnetic susceptibility measurements. The results suggest that all complexes are stable and molecular with octahedral coordination geometry for the Co(III) and Ni(III) complexes, square planar or tetrahedral geometry for the Cu(II) complex and a tetrahedral geometry for the Zn(II) complex. Evaluation of the antimicrobial activities of the ligands, metals salts and complexes on four bacterial strains (E. Coli, K.Pneumonia, S.typhi and S. flexneri) and four fungal strains (C. Albicans, C., Parapsilopsis, C. tropicalis and C. neoformans) showed higher activity of the complexes compared to the ligands and metals salts. The Co(III) complex showed higher activity than the reference drugs; doxycycline and Penicillin while the Cu(II) complex showed higher activity than the reference antibiotics; doxycycline and nystatin.

• #metal complexes synthesis and properties
• #synthesis and biological activity
• #inorganic and organometallic chemistry
• #chemistry

AutoDock and CB-Dock data for (NPA)6Zn3(H2O)2 in Synthesis, structural analysis, and docking studies with SARS-CoV-2 of a trinuclear zinc complex with N-phenylanthranilic acid ligands

Armel L. Mbani O., Awawou G. Paboudam, S. Chantal E. Stieber, Moise Ondoh Agwara

Zenodo (CERN European Organization for Nuclear Research)

AutoDock 4.2 and CB-Dock data for (NPA)6Zn3(H2O)2 with Mpro from SARS-CoV-2 from PDB Id: 6LU7.

• #computational drug discovery methods
• #metabolomics and mass spectrometry studies
• #crystal structures of chemical compounds
• #dock

AutoDock and CB-Dock data for (NPA)6Zn3(H2O)2 in Synthesis, structural analysis, and docking studies with SARS-CoV-2 of a trinuclear zinc complex with N-phenylanthranilic acid ligands

Armel L. Mbani O., Awawou G. Paboudam, S. Chantal E. Stieber, Moise Ondoh Agwara

Zenodo (CERN European Organization for Nuclear Research)

AutoDock 4.2 and CB-Dock data for (NPA)6Zn3(H2O)2 with Mpro from SARS-CoV-2 from PDB Id: 6LU7.

• #computational drug discovery methods
• #metabolomics and mass spectrometry studies
• #crystal structures of chemical compounds
• #dock

CCDC 1958341: Experimental Crystal Structure Determination

Donatus Bekindaka Eni, Divine Mbom Yufanyi‬, Nono Jean Hubert, Che Dieudonné Tabong, Moise Ondoh Agwara

The Cambridge Structural Database

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

• #crystallization and solubility studies
• #x-ray diffraction in crystallography
• #crystallography
• #materials science

CCDC 1958342: Experimental Crystal Structure Determination

Donatus Bekindaka Eni, Divine Mbom Yufanyi‬, Nono Jean Hubert, Che Dieudonné Tabong, Moise Ondoh Agwara

The Cambridge Structural Database

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

• #crystallization and solubility studies
• #x-ray diffraction in crystallography
• #crystal structure
• #crystallography

CCDC 1055785: Experimental Crystal Structure Determination

Feudjio Tsague Chimaine, Divine Mbom Yufanyi‬, Amah Colette Benedicta Yuoh, Donatus Bekindaka Eni, Moise Ondoh Agwara

The Cambridge Structural Database

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

• #crystallization and solubility studies
• #x-ray diffraction in crystallography
• #crystallography
• #materials science

CCDC 1417600: Experimental Crystal Structure Determination

Djuikom Sado Yanick Gaëlle, Divine Mbom Yufanyi‬, R. Jagan, Moise Ondoh Agwara

The Cambridge Structural Database

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

• #crystallization and solubility studies
• #x-ray diffraction in crystallography
• #crystallography
• #materials science

CCDC 1007918: Experimental Crystal Structure Determination

Amah Colette Benedicta Yuoh, Moise Ondoh Agwara, Divine Mbom Yufanyi‬, Mariam Aseng Conde, R. Jagan, Kenneth O. Eyong

The Cambridge Structural Database

• #crystallization and solubility studies
• #x-ray diffraction in crystallography
• #crystal structure
• #crystallography

CCDC 1418723: Experimental Crystal Structure Determination

Djuikom Sado Yanick Gaëlle, Moise Ondoh Agwara, Divine Mbom Yufanyi‬, Justin Nenwa, R. Jagan

The Cambridge Structural Database

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

• #crystallization and solubility studies
• #x-ray diffraction in crystallography
• #crystallography
• #crystal structure

CCDC 719425: Experimental Crystal Structure Determination

Moise Ondoh Agwara, Peter T. Ndifon, Mbom D. Yufanyi, Josepha N. Foba Tendo, Moses A. Atamba, Awawou G. Paboudam et 2 autre(s)

The Cambridge Structural Database

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

• #crystallization and solubility studies
• #x-ray diffraction in crystallography
• #crystallography
• #materials science

Sustainability in Nanomaterials Synthesis

Peter Ekane, Mbom Yufanyi, Moise Ondoh Agwara, Joseph Foba

• #chemistry and chemical engineering
• #sustainability
• #nanomaterials
• #nanotechnology

Solution Studies on Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Hexamethylenetetramine in Aqueous and Non-Aqueous Solvents

Awawou G. Paboudam, C. Gérard, Aminou Mohamadou, Moise Ondoh Agwara, Mariam Asseng Conde, Peter T. Ndifon

International Journal of Inorganic Chemistry

Potentiometric studies in aqueous medium and spectrophotometric study in non-aqueous medium were used to understand the behavior of hexamethylenetetramine (HMTA) complexes. The protometric studies of HMTA enabled us to confirm that only one basic site of this ligand is protonated in acidic medium and this ligand is decomposed in acidic medium. In aqueous medium, only hexa-aqua complexes in which HMTA is present in the second coordination sphere forming H-bonds with hydrogen atoms of coordinated and uncoordinated water molecules are obtained. In non-aqueous solvents, HMTA coordinates to metal ions displaying diversity in the structures of the resulting complexes in which HMTA can either be monodentate, bridged bidentate, tridentate, or tetradentate.

• #analytical chemistry and chromatography
• #inorganic and organometallic chemistry
• #electrochemical analysis and applications
• #hexamethylenetetramine

CCDC 652938: Experimental Crystal Structure Determination

Peter T. Ndifon, Moise Ondoh Agwara, Yoshihiko Hayashi, A. Uehara

Open MIND

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

• #crystallization and solubility studies
• #x-ray diffraction in crystallography
• #crystal structure
• #crystallography

<b>Synthesis, characterisation and antimicrobial activities of cobalt(II), copper(II) and zinc(II) mixed-ligand complexes containing 1,10-phenanthroline and 2,2’-bipyridine</b>

Moise Ondoh Agwara, Peter T. Ndifon, N.B. Ndosiri, Awawou G. Paboudam, Divine Mbom Yufanyi‬, Aminou Mohamadou

Bulletin of the Chemical Society of Ethiopia

Three new 1,10-phenanthroline and 2,2’-bipyridine mixed-ligand complexes of [Co(bpy)(phen)2](NO3)2.2H2O, [Cu(bpy)(phen) H2O)2]Cl2.2H2O, and [Zn(bpy)2(phen)]Cl2.6H2O were synthesized. The complexes were characterized by elemental, IR and visible spectroscopic analyses and the results indicate that both ligands are coordinated to the respective metal ions giving octahedral complexes. Antimicrobial studies showed that there is increased antimicrobial activity of the metal ions on coordination to the ligands. The water soluble complexes showed antimicrobial activities that are higher than those of the metal salts and 2,2’-bipyridine but lower than those of 1,10-phenanthroline. The copper complex [Cu(bpy)(phen)(H2O)2]Cl2.2H2O shows the highest activity. KEY WORDS: 1,10-Phenanthroline, 2,2’-Bipyridine, Mixed-ligand complexes, Antimicrobial activities, Cobalt(II), Copper(II), Zinc(II)Bull. Chem. Soc. Ethiop. 2010, 24(3), 383-389.

• #metal complexes synthesis and properties
• #inorganic and organometallic chemistry
• #synthesis and biological activity
• #chemistry

Synthesis, characterisation and crystal structure of a cobalt(II)-hexamethylenetetramine coordination polymer

Peter T. Ndifon, Moise Ondoh Agwara, Awawou G. Paboudam, Divine Mbom Yufanyi‬, Jean Ngouné, Agustı́n Galindo et 2 autre(s)

Transition Metal Chemistry

• #metal-organic frameworks: synthesis and applications
• #metal complexes synthesis and properties
• #crystal structures of chemical compounds
• #hexamethylenetetramine

<b>Synthesis and characterisation of some metal complexes of hybrid phosphorus-nitrogenligands: the crystal structure of 1-(diphenylphosphino)-2-(2-pyridyl)ethane cobalt(II) chloride</b>

Peter T. Ndifon, Moise Ondoh Agwara, Yoshihito Hayashi, Akira Uehara

Bulletin of the Chemical Society of Ethiopia

Some iron(II), cobalt(II) and copper(II) complexes of the hybrid ligand 1-(diphenylphosphino)-2-(2-pyridyl)ethane (dppe) and diphenyl-2-pyridylphosphine (dppp) have been synthesised and characterised. Analyses suggest tetrahedral structures in which the metal atoms are bonded to two chlorine atoms and to both phosphorus and nitrogen atoms for 1-(diphenylphosphino)-2-(2-pyridyl)ethane on one hand and on the other hand, bonding is through the nitrogen atoms of two molecules of diphenyl-2-pyridylphosphine, which acts as a monodentate ligand. The crystal structure of 1-(diphenylphosphino)-2-(2-pyridyl)ethane cobalt(II) chloride shows a pseudo-tetrahedral structure in which the aminophosphine is bonded to the cobalt centre through both the phosphorus and nitrogen atoms, forming a 6-membered ring. KEY WORDS: Aminophosphines, Metal complexes, Cobalt(II) complex, Crystal structure  Bull. Chem. Soc. Ethiop. 2008, 22(2), 253-260.

• #metal complexes synthesis and properties
• #organometallic complex synthesis and catalysis
• #inorganic and organometallic chemistry
• #chemistry

Synthesis and characterisation of some metal complexes of hybrid phosphorus-nitrogen ligands: the crystal structure of 1-(diphenylphosphino)-2-(2-pyridyl)ethane cobalt(II) chloride

Peter T. Ndifon, Moise Ondoh Agwara, Yoshihito Hayashi, Akira Uehara

DOAJ (DOAJ: Directory of Open Access Journals)

Some iron(II), cobalt(II) and copper(II) complexes of the hybrid ligand 1-(diphenylphosphino)-2-(2-pyridyl)ethane (dppe) and diphenyl-2-pyridylphosphine (dppp) have been synthesised and characterised. Analyses suggest tetrahedral structures in which the metal atoms are bonded to two chlorine atoms and to both phosphorus and nitrogen atoms for 1-(diphenylphosphino)-2-(2-pyridyl)ethane on one hand and on the other hand, bonding is through the nitrogen atoms of two molecules of diphenyl-2-pyridylphosphine, which acts as a monodentate ligand. The crystal structure of 1-(diphenylphosphino)-2-(2-pyridyl)ethane cobalt(II) chloride shows a pseudo-tetrahedral structure in which the aminophosphine is bonded to the cobalt centre through both the phosphorus and nitrogen atoms, forming a 6-membered ring.

• #phosphorus compounds and reactions
• #metal complexes synthesis and properties
• #organometallic complex synthesis and catalysis
• #cobalt

<b>Physicochemecal studies of some hexamethylenetetramine metal(II) complexes</b>

Moise Ondoh Agwara, Peter T. Ndifon, Maurice Kor Ndikontar

Bulletin of the Chemical Society of Ethiopia

Divalent metal (Mn, Co, Ni) complexes of the ligand hexamethylenetetramine (HMTA, C6H12N4) with sulfate, nitrate and fluoroborate as counter ions have been synthesized in ethanolic media. Whereas the complexes with BF4- and NO3- as counter ions have two molecules of hexamethylenetetramine, those with SO42- as counter ion contain just one molecule of hexamethylenetetramine. The complexes have been characterized by elemental analyses, infrared and visible spectroscopy and room temperature magnetic susceptibility measurements. The results suggest octahedral coordination in which the central metal ion is bonded to hexamethylenetetramine and water molecules. KEY WORDS: Divalent metal (Mn, Co, Ni) complexes, Hexamethylenetetramine, Sulfate as counter ion, Nitrate as counter ion, Fluoroborate as counter ion Bull. Chem. Soc. Ethiop. 2004, 18(2), 143-148.

• #inorganic and organometallic chemistry
• #various chemistry research topics
• #hexamethylenetetramine
• #chemistry

Protease Mutations in HIV-1 Non-B Strains Infecting Drug-Naive Villagers of Cameroon

Frank Konings, Ping Zhong, Moise Ondoh Agwara, Lucy Agyingi, Léopold Zekeng, Jacqueline M. Achkar et 5 autre(s)

AIDS Research and Human Retroviruses

To describe the presence of protease inhibitor (PI) resistance-associated mutations and subtype distribution in drug-naive villagers of six provinces of Cameroon, we sequenced the protease (PR) gene (297 bp) of 128 viruses. Secondary PI resistance-associated mutations were identified at five sites: L10I/V (16%), K20R (8%), M36I (98%), L63P (13%), and V77I (6%). No primary mutation in the PR was identified. Of the 128 specimens analyzed, subtypes A (11%), C(2%), D (6%), F2 (3%), G (6%), H (0.8%), J (6%), and CRF02_AG (60%) were identified. The mutations identified were not characteristic to any particular subtype. The absence of primary mutations, in addition to the few secondary mutations, gives good perspectives for PI treatment interventions in these rural areas.

• #hiv/aids drug development and treatment
• #hiv research and treatment
• #hiv/aids research and interventions
• #protease

Genetic and Biological Properties of HIV Type 1 Isolates Prevalent in Villagers of the Cameroon Equatorial Rain Forests and Grass Fields: Further Evidence of Broad HIV Type 1 Genetic Diversity

Ping Zhong, Sherri Burda, Frank Konings, Mateusz M. Urbanski, Liying Ma, Léopold Zekeng et 8 autre(s)

AIDS Research and Human Retroviruses

To understand the evolution of HIV-1, the genetic and biological characteristics of viruses that infect persons living in regions in which the virus has been evolving for several decades must be studied. Thus, we investigated teh genetic subtypes, coreceptor usage, and syncytium-inducing ability of viruses in 47 HIV-1-infected blood samples from individuals living in rural villages in the equatorial rain forest and grass field regions in Cameroon. Heteroduplex mobility analysis (HMA) of gag (part of p24 and p7) and env (C2V5) or sequence and phylogenetic analysis of gag (part of p24 and p7), pol (protease), and env (C2V5), revealed a broad HIV-1 group M genetic diversity. Subtype analysis revealed genetic evidence of seven subtypes (A, C, D, F, G, H, and J) and three circulating recombinant froms (CRFs) (CRF01_AE, CRF02_AG, and CRF11_cpx). Only 15 (32%) of the 47 samples analyzed revealed a concordant subtype in all three genes (gag, pol, and env), while discordant subtypes and CRFs were identified for the remaining 32 (68%) samples. Two patterns of HIV-1 diversity could be discerned in two provinces. While more concordant subtypes in gag, pol, and env genes were identified in villages of South province (10 of 13, 77%), the HIV-1 diversity in the West province was characterized by intersubtype recombinants (63%). Five new intersubtype recombinants were identified including Agag Jpol Genv, Ggag Upol Aenv, AGgag Jpol Aenv, Agag AGpol Henv, and Cgag AGpol AGenv. All of the 40 viruses tested used the R5 coreceptor, of which four also used the X4 coreceptor. Four viruses were able to induce syncytia in MT-2 cells, however, syncytium induction did not correlate with coreceptor usage. This study further reveals the complexity of HIV-1 infection in rural Cameron and points to the future of the global epidemic, which may be characterized by more genetically diverse viruses.

• #hiv research and treatment
• #hiv/aids research and interventions
• #hiv/aids drug development and treatment
• #genetic diversity