Ernestine ZONDEGOUMBA

Phytochemical Composition and Biological Activity of Faidherbia albida (Mimosaceae) Roots and Leaves

Tchebemou Bakang Bruno, Soh Desire, Nkwengoua Tchouboun, Zondegoumba Ernestine, Nganso Yves Oscar Ditchou, Yves Oscar et 3 autre(s)

International Journal of Pharmaceutical Sciences Review and Research

Phytochemical composition of roots and leaves of Faidherbia albida, let to the isolation and the identification of fourteen ( The structures of all the isolated constituents were determined by a comprehensive use of spectroscopic analysis such as 1D-and 2D-NMR, EI-MS, and ESI-MS coupled with the comparison of data thereof obtained with those of known analogs listed in the literature. These compounds and various extracts, fractions were investigated for their antioxidant potential, and antischistosomal and antifungal effects against Schistosoma mansoni and Candida albicans respectively, -Glucosidal and Trypsin activity. The results revealed that all the extracts (roots and leaves), exhibited antifungal, antioxidant and enzyme -Glucosidase inhibition activities. Moreover, Quercetin-3-O--rhamnoside (13) inhibited -Glucosidase, Trypsin and Schistosoma mansoni. The synergic effect of the extract and fraction, and also their triple of Quercetin-3-O--rhamnoside (13) could classified Faidherbia albida among the potential candidate for the development of multitarget drugs. This could reduce the combination of multiple biological active agent (multitherapy) therapy in favor of multitarget drug strategies.

2016Article de revueAccès ouvert

Chemical Constituents of Dissotis perkinsiae (Melastomaceae) and Their Antimicrobial Activity

Tchebemou Bakang Bruno, Nganso Ditchou Yves Oscar, Soh eacute, Zondegoumba Ernestine, Toghueo Marie, Sidjui Sidjui Lazare et 2 autre(s)

Journal of Applied Pharmaceutical Science

The phytochemical study of the Methanol/dichloromethane extract of the leaves of Dissotis perkinsiae led to the isolation and identification seven compounds: Ursolic acid (1); Sitosterol--D-glucoside (2); Isoquercitrin (3);Quercetin-3-O--galactoside (4);Kaempferol-3-O--D-glucoside (5); Kaempferol-7-O--D-glucoside (6); Trans-Tiliroside (7). Their structures were elucidated on the basis of spectroscopic analysis and by comparison of their spectral data with those reported in the literature. The results of antimicrobial activity indicated that the MIC vary from >0.5 to 0.00078 mg/mL on yeasts and from >0.5 to 0.25 mg/mL on bacteria. Sitosterol--Dglucoside was the most active with the broad spectrum (MIC=0.125mg/mL on C. albicans, MIC=0.0625 mg/mL on C. kruseiand MIC=0.0078 mg/mL on C. parapsilosis). Kaempferol-7-O--D-glucoside was the most active on C. krusei (MIC=0.0039 mg/mL). The anti yeat activity of Sitosterol--D-glucoside and Kaempferol-7-O--D-glucoside were better thanfluconazole (0.032mg/mL) on C. parapsilosis (MIC 0.0078 mg/mL) and C. krusei (0.0039 mg/mL) respectively. Sitosterol--D-glucoside and Trans-Tiliroside showed weak inhibitotry activity against S. enteric and S. aureus with MIC value of 0.5mg/mL. Respectively this inhibitory effect was lower activities observed with Chloremphenicol and Ampicillin (0.000488 mg/mL). The results of this study suggest that Dissotis perkinsiae represent an untapped source of compounds with potential antimicrobial activity that could be explored in the development of new therapeutic natural products.

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Ernestine ZONDEGOUMBA

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2020

Phytochemical Composition and Biological Activity of Faidherbia albida (Mimosaceae) Roots and Leaves

2016

Chemical Constituents of Dissotis perkinsiae (Melastomaceae) and Their Antimicrobial Activity

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