Publications scientifiques
Yannick Sani Jignoua
Paulin Teko Keumedjio
Marie Louise Coute-Chère Mbog
Asian Journal of Pharmacy and Pharmacology
Objective: Aluminum chloride can induce toxicity of the reproductive system leading to infertility which is a real public health problem.This study was undertaken to investigate the effect of Engl.& Diels in vivo Terminalia superba aqueous extract on aluminum chloride-induced reprotoxicity in male rats.Thirty male Materials and methods: Wistar rats of 12 weeks each, weighing 160 -180 g were intraperitoneally administered aluminum chloride (20 mg/kg, body weight) for 56 days.The rats were subsequently orally treated for 56 days with Engl.& Diels Terminalia superba aqueous bark extract at doses of 43 and 86 mg/kg and a coadministration of vitamin E (100 mg/kg) and zinc (50 mg/kg).Then, the rats were killed, and blood, testes, epididymis, seminal vesicle and prostate were removed for histological and biochemical analysis.Aluminum chloride caused significant decreases in the sexual performance of the male Results: rats, sperm quality, catalase activity and glutathione levels (P < 0.05).The serum testosterone and fructose levels were also significantly lower in the intoxicated group (P <0.05) than in the normal control group, with decreases of 91.25 % and 8.80 % respectively.In addition, histological lesions were observed in the testes, epididymis and prostate of the intoxicated group.Our results revealed that the aluminum chloride-induced reprotoxicity was reversed by the aqueous extract of Engl.& Diels.Oral administration of an aqueous extract of Terminalia superba Terminalia Conclusion: superba ; Engl.& Diels at the dose of 86 mg/kg, can alleviate the aluminum chloride-induced reprotoxicity in male rats.
