Scientific publications
Antoine Kada Sanda* (Corresponding author)
Other affiliations: University of Bamenda
Messmer Faleu Nya Ngassam
Paul Désiré Djomeni Dzeufiet
Pièrre Kamtchouing
Pierre Watcho
Pierre Miegueu
Pharmaceutical Biology
CONTEXT: Medicinal plants have become a great source of relief for more 70% of the population in developing countries where access to modern medicine is very limited. Some of these plants are used as aphrodisiac agents. The stem bark of Allanblackia floribunda Oliver (Clusiacea) has been used in Cameroon as an aphrodisiac. OBJECTIVE: This study was designed to assess the effects of Allanblackia floribunda aqueous and ethanol extracts and their potential mechanism on fictive ejaculation in spinal male rats. MATERIALS AND METHODS: Electromyographic activities of the bulbospongiosus muscles were recorded in 24 groups of spinal rats after intravenous administration of aqueous and ethanol extracts (2.5, 10, 20, 40 or 60 mg/kg) from the stem bark of A. floribunda in the presence or absence of dopamine (60 mg/kg). Furthermore, electromyographic activities of the bulbospongiosus muscles were recorded in five groups of spinal rats pre-treated orally during 8 d with extracts (150 and 300 mg/kg) in the presence of dopamine. RESULTS: Sequential treatments of rats with extracts significantly decreased the occurrence of ejaculation induced by dopamine up to 88.94% inhibition. The oral pre-treatment with both extracts significantly decreased the ejaculation induced by dopamine with the highest inhibition of 89.79%. DISCUSSION AND CONCLUSION: Two extracts of A. floribunda used in this study had inhibitory activities on ejaculation. The inhibitory effect of A. floribunda extracts on fictive ejaculation in rat may be directly mediated through dopaminergic pathways. Inhibition of ejaculation caused by these extracts could support its use in patients suffering from rapid ejaculation.
