Scientific publications
Janvier Youovop
Christelle Mbopda
Felix Nwang
Raissa Francoise Ntentie
Mary-Ann Angie Mbong
Julius E. Oben
Guy Roussel Takuissu
Harinder Singh
Functional Foods in Health and Disease
Introduction: Previous studies have shown the beneficial effects of Dyglomera®, a hydroethanolic extract of Dichrostachys glomerata, on inflammation as well as parameters linked to metabolic syndrome. Its effect on body fat was however not verified. The present study was therefore carried out to evaluate the anti-obesity effect of the Dyglomera®, on overweight and obese subjects.Methods: This 12-week randomized, double-blind placebo-controlled trial had percentage body fat measured by dual-energy X-ray absorptiometry, body weight and body mass index set as efficacy endpoints. On the other hand, key biochemical parameters were measured as secondary endpoints. The values of these parameters at T12 compared to T0 for the placebo and Dyglomera® groups were used as a measure of the efficacy. Results: Subjects treated with Dyglomera® for 12 weeks showed significant differences, with 6.73 kg (p<0.05) decrease in the body weight and 22.85% (p<0.05) reduction in the percentage body fat. In addition, the markers of lipid profile, adipocytokines, glycemia and transaminases plasmatic activities were also improved by the intake of Dyglomera®.Conclusions: This study shows that Dyglomera® effectively decreases the body weight in obese subjects after 12 weeks of treatment, which was accompanied by a reduction in the body fat and related disorders. Dyglomera®is a good agent for overweight and obesity management.Keywords: Dichrostachys glomerata, Dyglomera®, body fat percentage, body weight, clinical trials.
