Scientific publications
* (Corresponding author)
Pièrre Kamtchouing
Aboubakar Bibi-Farouk Oumarou
Other affiliations: Université de Garoua
Bopda Mtopi Orelien Sylvain
Kameni Poumi Mireille
Ngapout Fifen Joseph Rodrigue
Kahou Tadah Rivaldo Bernes
Dzeufiet Djomeni Paul Désiré
Clinical Traditional Medicine and Pharmacology
ABSTRACT Background Many plant extracts have been found to be able to treat hypertension and prevent related reproductive system impairments. Aqueous extract of a mixture of leaves from Persea americana , aerial parts of Cymbopogon citratus, fruit of Citrus medica and honey (named PECINEY), has proved to be effective in the management of hypertension on rats. Objective The aim of this study is to assess the effects of PECINEY on reproductive system of alcohol-induced hypertensive wistar male rats. Methods Hypertension was induced by oral administration of ethanol (31.56 mg/l; 5 g/kg body weight) to the rat during six weeks. Concomitantly, distilled water, PECINEY aqueous extract (100 and 150 mg/kg) or nifedipine (10 mg/kg) were giving to different groups. One group also received, in addition to alcohol, Viagra the 21 st and 42 nd days, before sexual behavioural and muscle strength evaluation. At the end of the treatment period, hemodynamic parameters were recorded and sacrifices performed. Blood from the abdominal artery and some organs (penis epididymis, testis, liver and kidney) were collected for biochemistry parameters assay and histology. Results PECINEY aqueous extract was able to prevent the rise in blood pressure induced by alcohol on rats, as well as the associated dyslipidaemia, oxidative stress, sexual motivation and performance and muscle strength impairments. In the same model, PECINEY also preserved spermatogenesis as well as seminal vesicle and epididymis structure and function. Conclusion The management of hypertension with PECINEY could then preserve the integrity of reproductive system in a model of alcohol-induced hypertension in male rat.
