Scientific publications
2026Journal articleEnglishOpen access
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Scientific publications
Benjamin Koko* (Corresponding author)
Orélien Sylvain Mtopi Bopda
Paul Aimé Noubissi
Cleabert Nwombobue Nkwemeh
Journal of Biosciences and Medicines
Introduction: Worldwide, 32% of deaths are due to cardiovascular diseases, including myocardial infarction (MI). Persea americana (Lauraceae) is a plant traditionally used in Cameroon against arterial hypertension and diabetes. This study aimed at investigating the cardioprotective properties of Persea americana (P. americana) leaf aqueous extract on two cardiac biomarkers and the myocardium architecture in a rat model of isoprenaline (ISO)-induced MI. Methods: Thirty (30) adult Wistar rats were randomly distributed into six (6) groups of five (5), and then treated for twenty-eight (28) days. There were three control groups: neutral control (water 10 mL/kg; 28 days), negative control (ISO 150 mg/kg; day 27 and 28) and positive control (propranolol 10 mg/kg; day 19 -28 + ISO 150 mg/kg; day 27 and 28). Three test groups received P. americana extract (50, 100 or 200 mg/kg, respectively) for 28days, and ISO (150 mg/kg) 2 days prior to sacrifice. Myocardial infarction was induced in the rats using subcutaneous injection of 150 mg/kg/day Isoprenaline (ISO) for two consecutive days (27th and 28th) at 24 hours interval. Food and water consumption and body weight were recorded during this period of treatment. Recordings and treatments were done at 10 am every day. Rats were sacrificed on day 29 at 10 am and blood was collected for analysis. Heart weight was measured. Serum levels of Creatine kinase-MB and Troponin I were determined. A histopathological study of the cardiac tissues was done. ANOVA, followed by a multiple comparison turkey test was used for statistical analyses. P Results: Troponin level was 14.49 ± 2.58 µg/L in the neutral control group. ISO significantly (P P. americana extract (50, 100, and 200 mg/kg) dose-dependently and significantly (P P. americana extract (50, 100, or 200 mg/kg) dose-dependently and significantly (P Conclusion: Persea americana aqueous extract is cardioprotective against ISO-induced MI and can be used to prevent cardiac arrests.