Publications scientifiques
Tchoupou Tchinda Huguette
Ngueguim Tsofack Florence
Gounoue Kamkumo Raceline
Aboubakar Oumarou Bibi Farouck
Bella Ndzana Martin Thierry
World Journal of Pharmaceutical and life sciences
Eleusine indica is traditionally used in Cameroonian folk medicine to treat several diseases including renal and hepatic disorders. The present study was to evaluate hepato-nephroprotective effects of Eleusine indica aqueous extract against gentamicin-induced hepatic and renal toxicity in rat. Rats were divided into control group and experimental group. Control group was pretreated intraperitoneally (ip) with saline 0.9 % (1 mL/100 g) during 10 days, while experimental group was pretreated by administration of gentamicin (ip route) at the dose of 100 mg/kg during 10 days. Animals of experimental group were then subdivided into four groups treated during twenty consecutive days as follow: control group: rats were treated with 0.9 % NaCl ip, negative group: rats were receiving gentamicin (100 mg/kg), positive group: rats were receiving gentamicin and aspirin (80 mg/kg), extract group I and II: rats were receiving gentamicin and Eleusine indica aqueous extract (100 and 200 mg/kg). The effects of…
