Publications scientifiques
2009Article de revueespagnolAccès ouvert
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Publications scientifiques
Dzeufiet Djomeni
Paul Désiré
Ngeutse Donfouet Florine
Ngueguim Tsofack Florence
Tchamadeu Marie-Claire
Sokeng Dongmo Sélestin
Pièrre Kamtchouing
Summary The potential of dietary Irvingia gabonensis seed extract in ameliorating hyperglycemia and hyperlipidemia was investigated in streptozotocin (STZ)induced diabetic rats. In a 4-week feeding trial, incorporation of Irvingia gabonensis seed extract (10%) in the diet of diabetic rats was found to significantly reduce the plasma glucose level of STZ diabetic rats. The total food intake was significantly reduced in the diabetic rats fed 10% Irvingia gabonensis seed extract compared to the control diabetic rats. However, the body weight gain over 28 days was more than 2.5 times greater in Irvingia gabonensis seed supplemented diabetic rats compared to the control diabetic rats. Irvingia gabonensis seed in the diet also decreased the elevated serum total cholesterol, triglycerides and LDL-cholesterol levels as well as atherogenic index while increasing HDL-cholesterol. The result of these studies clearly establishes the modulatory propensity of Irvingia gabonensis seed against diabetes induced dyslipidemia. Irvingia gabonensis seed could be effectively used as an ingredient in health and functional food to ameliorate certain disease states such as diabetes.