Publications scientifiques
2009Article de revueanglaisAccès ouvert
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Publications scientifiques
Fidèle Ntchapda
Yolande Gisèle
Mbongue Fandio
Summary Celtis durandii is a medicinal plant highly used in Cameroon for the treatment of cardiovascular disorders. The vasorelaxant effects of the aqueous extract leaves of C. durandii were examined on isolated rat thoracic aorta. The relaxant effects of C. durandii on vascular preparation from rat aorta precontracted with KCl or norepinephrine was concentration dependent. This relaxing effect was significantly reduced with KCL-induced contraction following mechanical damage to the aortic endothelium. In the presence of Tetraethylammonium (10 -6 M), the extract at concentrations of 1.75 mg/ml, 5.25 mg/ml and 8.75 mg/ml, did not produce significant modifications between the vasorelaxation induced by the extract in the normal physiological medium. Relaxation elicited by C. durandii were not significantly affected by glybenclamide (10 -6 M), a non selective K + channel blocker. Indomethacine (10 -6 M) significantly inhibited relaxation induced by the plant extract. At concentration of 1.75 mg/ml, 5.25 mg/ml, and 8.75 mg/ml, relaxation was 15.64 %, 36.53 %, and 72.12 % respectively. These findings indicate that the vasorelaxation effect of the aqueous extract leaves of C. durandii may be mediated at least in part by prostacyclin.