Publications scientifiques
2007Article de revueanglaisAccès ouvert
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Publications scientifiques
Paul Vernyuy Tan
George Enow-Orock
François‐Xavier Etoa
Pauline Bitolog
Summary Enantia chlorantha Oliver (Annonaceae), widely used in Cameroonian folk medicine, has been previously shown to possess anti-ulcer, anti- trypanosomial and antiHelicobacter properties. Other investigations have revealed the anti-malarial, antiviral, antibacterial and anti-hepatotoxic properties of this plant. In the present study the acute and sub-acute toxicity profiles of the aqueous stem-bark extract was evaluated. Swiss mice were administered single oral doses of 1000, 3000 and 5000 mg/kg and monitored for death and growth impairment for seven days (acute toxicity). In sub-acute toxicity, experimental rats, received daily doses of 250, 500, and 1000 mg/kg for 42 consecutive days and the toxic effects of the extract were assessed using biochemical and haematological parameters as well as the study of histological sections of vital body organs ( heart, lungs, liver, kidneys, spleen, gonads and stomachs). No death or growth impairment was noticed in the mice in acute toxicity test. At 1000 mg/kg in the sub-acute toxicity study, the rats presented histopathological signs in the liver, lungs and kidneys, as well as significant (P< 0.05) increases in values of ALT, AST and platelet counts. The rest of the organs studied showed no signs of pathology. The extract of E. chlorantha, is not toxic in acute intake up to 5000 mg/kg, but can cause lung, hepatic and kidney disorders following medium-to-long term use at doses greater than 500 mg/kg.