Publications scientifiques
Kenneth O. Eyong
Hidayat Hussain
Michael Saeftel
Salem Ramadan Sarite
Achim Hoerauf
Karsten Krohn
Fourteen novel phenazines, together with seven known phenazinic derivatives were synthesized through solid state chemistry by reaction of �-lapachone and eight other o-quinones with four different ortho-diamines, and screened against Plasmodium falciparum in vitro . The pyrido-phenazine derivatives showed the greatest suppression of parasitic growth while the 1,2-dichloro-derivatives exhibited the least activity for a given ortho-diamine. With respect to the ortho-quinones, the phenazines obtained from �-lapachone gave the best results.
