Publications scientifiques
2007Article de revueanglaisAccès ouvert
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Publications scientifiques
Bopda Mtopi
S.V. Rakotonirina
Pièrre Kamtchouing
Summary Brillantaisia nitens Lindau (Acanthaceae) is traditionally used in Cameroon for the treatment of many diseases including cardiovascular disorders. We have studied the effect of the methylene chloride/methanol (CH2Cl2/CH3OH) leaf extracts of B. nitens on rat arterial blood pressure and heart rate in normotensive wistar rats (NTR), salt laoded hypertensive rats (SLHR), DOCA-salt hypertensive rats (DSHR) and L-NAME hypertensive rats (LNHR), using the direct cannulation method. Intravenous (i.v.) administration of the plant extract (5-80 mg/kg) resulted in a biphasic dose-related hypotensive effect. At the dose of 10 mg/kg, the extract produced a rapid decrease of systolic blood pressure (SBP) by 14%, 16%, 14% and 23% in NTR, SLHR, DSHR and LNHR, respectiveley. In the same animal models, the dose of 40 mg/kg caused decreases of 39%, 26%, 20%, and 34%, respectively. The immediate fall of SBP induced by the plant