Publications scientifiques
DT Noungoue
Joseph Ngoupayo
BL Ndjakou
FF Boyom
Etienne Tsamo
Saliou Ngom
Mehdi Chaabi
Cyril Antheaume
J. Gut
PJ Rosenthal
Annelise Lobstein
Planta Medica
In the framework of our interest in antimalarial natural products from Clusiaceae family [1,2], the apolar extract of the stem bark of Vismia laurentii showed good antimalarial activity (IC 50 =4.6µg/ml). Thus, the isolation of its constituents led to the identification of a new tetracyclic triterpene, (20-ethylnortirucalla-7,24-dien-3-one) vismiaturucallone ( 1 ) (Fig.1) along with eight known compounds namely 3-geranyloxyemodin, vismiaquinone A ( 3 ), vismiaquinone B, bivismiaquinone, epifriedelinol, betulinic acid, tirucalla-7,24-dien-3-one, and stigmasta-7,22-dien-3-ol. Compounds ( 1 ) and ( 3 ) showed antiplasmodial activity against chloroquine-resistant W2 strain of Plasmodium falciparum with IC 50 of 1.17µM and 1.42µM, respectively. Fig.1 References: [1] Ngouela, S. et al. (2005) Nat Prod Res 19(7):685–8. [2] Ngouela, S. et al. (2006) Phytochemistry 67(3):302–6.
