Publications scientifiques
Valery Wilfried Nguemdjo Chimeze* (Auteur correspondant)
Autres affiliations : TU Dortmund University
Céline Mbazoa Djama*
Ezgi Eyluel Bankoglu* (Auteur correspondant)
Helga Stopper
Sebastian Zühlke
Dennis Eckelmann
Véronique Simone Fannang
Jovita Chi Shirri
Ernestine Nicaise Djuidje
Natural Product Research
A phytochemical investigation of the liana of Artabotrys thomsonii led to the isolation of a new oxoberberine alkaloid, 2,10-dihydroxy-3,9-dimethoxy-8-oxo-protoberberine (7), along with six known compounds. Their chemical structures were elucidated by 1 D and 2 D NMR spectroscopic methods and HRESI-MSn data analysis. Compounds 4 and 7 were selected for further in vitro investigations. In accordance with expectations from their chemical structures, compounds 7 and 4 showed a clear antioxidant activity in a cell-free assay, with compound 7 being 7-fold more active than 4. Cytotoxicity, cytostatic and genotoxic effects only occurred at high micromolar concentrations of 50 µM or more. Compound 7 was slightly less effective than compound 4. A low micromolar concentration of 10 µM did not cause any damaging cellular effects but showed potential for a protection against the micronucleus-inducing effect of reactive oxygen species hydrogen peroxide, although not to a significant extent.
