Publications scientifiques
Marcelle Oliviane Ngangoue
Bathélémy Ngameni
Godloves Fru
Ghislain W. Fotso* (Auteur correspondant)
Bonaventure T. Ngadjui
Brice E. N. Wamba
Victor Kuete
Japheth O. Ombito
Gomotsang Bojase
Natural Product Research
The chemical investigation of Anonidium mannii root extract by column chromatography techniques led to the isolation of eight compounds among which two previously unreported compounds; a lanostane-type triterpene, lanosta-7,9(11),23-triene-3β,15α-diol 1 and an alkaloid, 9-hydroxy-8-methoxyphenanthridin-6(5H)-one 2 along with six known compounds: lanosta-7,9(11),24-triene-3β,21-diol 3, oxoanolobine 4, 3, 4-dihydroxybenzoic acid 5, stigmasterol 6, β-sitosterol 7 and 3-O-β-D-glucopyranosyl-β-stigmasterol 8. Their structures were established from spectral data, mainly HR-ESIMS, 1 D and 2 D NMR and by comparison with literature data. The crude root and stem bark extracts (AMR and AMB) and the isolated compounds (1–8) were tested against nine Gram-negative bacteria using rapid p-iodonitrotetrazolium chloride ≥97% (INT) microdilution technique. It was found that AMR, AMB and compound 5 were active against the nine tested bacteria with MIC values ranging from 64 to 1024 µg/mL. Compounds 1–4 had selective antibacterial activities whilst 6–8 were not active.
