Publications scientifiques
* (Auteur correspondant)
Faustin Pascal Tsagué Manfo* (Auteur correspondant)
C. Harthé
Edouard Akono Nantia
H. Déchaud
Autres affiliations : Inserm · Hospices Civils de Lyon
Marie-Tthérèse Zabot
Autres affiliations : Inserm · Hospices Civils de Lyon
Michel Pugeat
Autres affiliations : Inserm · Hospices Civils de Lyon · Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition
Toxicology and Industrial Health
The consequences of bisphenol A (BPA) exposure on male reproductive function were studied in two populations from Cameroon, farmers using agro pesticides in Djutitsa (rural area) and townsmen in Yaoundé (urban area, Centre region). Urinary BPA concentration from all participants was measured, and the values were correlated with biochemical markers of male reproductive function. The data showed that BPA could be detected in 92.6% of urine participants, with an average concentration of 2.18 ± 1.97 µg/g creatinine but with no significant difference between the urinary BPA concentration from rural and urban populations. From BPA urinary concentration, the BPA average daily intake was estimated to be 0.06 ± 0.05 μg/kg/day (3.51 µg/day per individual) in the Cameroon population. Interestingly, free and bioavailable testosterone concentrations and estradiol/testosterone ratio correlated with BPA levels in the overall population. When data were analysed according to residence, BPA correlated with total testosterone levels ( r = -0.433) and estradiol/testosterone ratio ( r = 0.338) in the urban residents only, while the rural population exhibited significant increases in sex-hormone-binding globulin with increased BPA exposure. Our data showed that the male Cameroon population is exposed to BPA but that inconstant BPA association to endocrine reproductive markers suggests that other environmental factors in combination with BPA exposure might influence testicular function.
