Publications scientifiques
Arnaud Fondjo Kouam
Autres affiliations : University of Buea
Ferdinand Elombo Kouoh
Rodrigue Fifen
Mayelle Mepa Mokam
Eléonore Ngounou
Kerinyuy Juliene Kongnyuy
Elisabeth Zeuko’o Menkem
Nembu Erastus Nembo
Emmanuel Acha Asongalem
Pascal Dieudonné Chuisseu Djamen
PubMed
Objective: against gentamicin-induced hepato-renal toxicity. Materials and Methods: antioxidant activities. Then, their cytoprotective effects were assessed against gentamicin-induced cytotoxicity in primary mouse hepatocytes. Finally, mice were administered with gentamicin (20 mg/kg) and co-treated with HAG for 14 days, and histopathology, biochemical and molecular parameters related to gentamicin-induced toxicity were evaluated. Results: HAG exhibited outstanding chemical antioxidant activities and preserved hepatocytes from gentamicin-induced cytotoxicity. HAG relieved liver and kidney histopathological and biochemical changes, and enhanced the mRNA level of Nrf2 and its target gene HO-1 in gentamicin-intoxicated mice. Conclusion: HAG attenuates hepato-renal injuries induced by 14-days administration of gentamicin in mice through the activation of Nrf2-antioxidant signaling pathways.
