Publications scientifiques
Joseph T Mbafor
Z. Tanee Fomum
Won Keun Oh
Hyun Sun Lee* (Auteur correspondant)
Bo Yeon Kim
Jong Seog Ahn
Hye Kyung Chang
Yong Hae Kim
Phytotherapy Research
Auriculatin and 8-prenylluteone were isolated from Erythrina senegalensis (Leguminosae) as inhibitors of phospholipase C (PLC) and phosphoinositides (PI)-turnover in PLC-γ1 overexpressing NIH3T3 fibroblasts (NIH3T3γ1). Auriculatin (1) and 8-prenylluteone (2) showed inhibitory activity with an IC50 value of 20 μm on PLC in vitro as well as the formation of inositol phosphates in platelet-derived growth factor (PDGF)-stimulated NIH3T3γ1 cells. They also showed a moderate cytotoxicity against several human tumour cell lines with an IC50 of 9.0–20 μm, i.e. PC-3 (prostate), NCI-H226 (lung), CRL1579 (melanoma) in vitro. © 1998 John Wiley & Sons, Ltd.
