Publications scientifiques
Bruno Ndjakou Lenta* (Auteur correspondant)
Joél T. Ateba
Jean Rodolphe Chouna
Makoah N. Aminake
Gabriele Pradel
Flore Nardella
Autres affiliations : Université de Strasbourg
Catherine Vonthron‐Sénécheau
Autres affiliations : Université de Strasbourg
Beate Neumann
Hans‐Georg Stammler
Norbert Sewald
Helvetica Chimica Acta
Abstract Phytochemical investigation of the leaves of Phragmanthera capitata collected on Cassia spectabilis tree led to the isolation of two natural lactones, rel ‐(1 R ,5 S ,7 S )‐7‐[2‐(4‐hydroxyphenyl)ethyl]‐2,6‐dioxabicyclo[3.3.1]nonan‐3‐one ( 1 ) and 4‐{2‐[ rel ‐(1 R ,3 R ,5 S )‐7‐oxo‐2,6‐dioxabicyclo[3.3.1]non‐3‐yl]ethyl}phenyl 3,4,5‐trihydroxybenzoate ( 2 ) together with the known compounds betulinic acid ( 3 ), dodoneine ( 4 ), quercetin 3‐ O ‐ α ‐ L ‐rhamnopyranoside ( 5 ), quercetin 3‐ O ‐ α ‐ L ‐arabinofuranoside ( 6 ), quercetin ( 7 ), betulin ( 8 ), lupeol ( 9 ), and sitosterol ( 10 ). Their structures were established by means of modern spectroscopic techniques, and the relative configuration of compound 1 was confirmed by X‐ray analysis. Compounds 1 and 2 were tested in vitro for their antiplasmodial activity against the Plasmodium falciparum chloroquine sensitive‐strains NF54 and 3D7. Compound 2 exhibited good antiplasmodial activity against both strains with IC 50 of 2.4 and 4.9 μ M , respectively, while compound 1 was inactive.
