Publications scientifiques
Iliassou L. Mouafon
Autres affiliations : University of Karachi · International Center for Chemical and Biological Sciences
Bel Youssouf G. Mountessou
Joseph Tchamgoue
Bonaventure T. Ngadjui
Siméon F. Kouam* (Auteur correspondant)
Mehreen Lateef
Muhammad Shaiq Ali
Autres affiliations : International Center for Chemical and Biological Sciences
Ivan Robert Green
Natural Product Research
Iliassou Lah Mouafonabc, Bel Youssouf Gbetnkom Mountessoua, Mehreen Lateefd, Joseph Tchamgouea, Muhammad Shaiq Alic, Jean Claude Tchouankeua, Ivan Robert Greene, Bonaventure Tchaleu Ngadjuia & Simeon Fogue Kouamb*a Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroonb Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé, Cameroonc H.E.J. Research Institute of Chemistry, International Centre for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistand Multidisciplinary Research Lab (MDRL), Bahria University Medical and Dental College, Karachi, Pakistane Department of Chemistry and Polymer Science, University of Stellenbosch, Matieland, Stellenbosch, South AfricaSupplemental data for this article can be accessed online at https://dx.doi.org/10.1080/14786419.2022.2041007.CONTACT Simeon Fogue Kouam kfogue@yahoo.comAbstractThe phytochemical investigation of a previously unstudied species of the genus Indigofera, I. atriceps Hook.f. was undertaken and two new phenolic compounds, atricephenols A (1) and B (2) were isolated, along with nine known secondary metabolites viz., (-)-melilotocarpan D (3), genistein (4), melilotocarpan A (5), maackiain (6), p-hydroxybenzaldehyde (7), bornesitol (8), β-sitosterol (9), sitosterol-3-O-β-D-glucopyranoside (10) and stigmasterol-3-O-β-D-glucopyranoside (11). Their structures were elucidated by extensive NMR spectroscopic analyses and HRESIMS, and by comparing their data with those reported in the literature. Compounds 1, 4, 7–11 were tested for their antibacterial efficacies and for their potential to inhibit the enzyme urease. Compounds 7 and 9 showed significant antibacterial activity against Salmonella typhi (ZOIs of 13 and 15 mm, respectively), while the best urease inhibition was measured for compound 9 with an IC50 value of 18.6 µM, which is higher than that of the potent inhibitor, thiourea (IC50 = 21.5 µM).Graphical Abstract
