Publications scientifiques
Salome Y. Ghansenyuy
Kenneth O. Eyong* (Auteur correspondant)
Pierre Yemback
Mehreen Lateef
Vincent de Paul N. Nziko
Muhammad Shaiq Ali
Autres affiliations : International Center for Chemical and Biological Sciences
European Journal of Medicinal Chemistry Reports
The phytochemical study was carried out on the ethanolic extract of the leaves of Alstonia scholaris. This plant has been used traditionally for medicinal purposes in the treatment of several diseases such as cancer, jaundice, malaria, gastrointestinal troubles, dysentery, snake-bite and diarrhea. Chromatographic purification of this extract led to the isolation and characterization of nine compounds. Their structures were elucidated as betulin (1), α-amyrin acetate (2), mixture of β-sitosterol (3) and stigmasterol (4), tetratriacontyl-trans-p-coumarate (5), ursolic acid (6), picralstonine (7), β-sitosterol glucoside (8) and scholaricine (9). Scholaricine and β-sitosterol-glucoside exhibited potent lipoxygenase inhibitory activity with IC50 of 15.2 ± 0.41 and 18.5 ± 0.14 respectively compared to Baicalein (22.6 ± 0.08) used as positive control. Molecular docking studies were conducted to support lipoxygenase inhibitory activities of the test compounds.
