Publications scientifiques
Joseph Tsemeugne
Yetiny Atuh Bah
Jérôme N. Ndefongang
Pamela Kemda Nangmo
Blandine Marlyse Wache Ouahouo
Augustin E. Nkengfack
Jean Paul Dzoyem
Autres affiliations : Onderstepoort Veterinary Academic Hospital · University of Pretoria
Emmanuel F. Sopbué
Ibukun M. Famuyide
Autres affiliations : University of Pretoria
Lyndy J. McGaw
Autres affiliations : University of Pretoria
Giles Edwards
Peter F. W. Simon
Apollinaire Tsopmo
ARKIVOC
A series of novel tetrazine derivatives, containing benzothiazole framework, were prepared during the coupling reactions of some diazotized 2-aminobenzo[d]thiazole derivatives with p-acetaminophen. Their structures were elucidated based on NMR and MS spectrometry. The anticancer activity and the safety of the synthesized compounds along with the entire precursors were assessed against three human cancer cell lines and a normal cell line. All the synthesized compounds showed selective cytotoxic activity against the cancer cell lines used in comparison to the normal Vero cell line. Their IC50 values varied from 2.02 to 171.67 M.
