Publications scientifiques
2026Article de revueanglais
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Publications scientifiques
Mireille Flaure Metchi Donfack
Gwladys Nyanga Nkomo
Marius Mbiantcha
Fidèle Ntchapda
Investigational Medicinal Chemistry and Pharmacology
Background: The pharmacological properties of Cinnamomum zeylanicum have been predominantly explored in the context of cardiovascular diseases. Given its well-established anti-inflammatory and antioxidant properties, this study aimed to evaluate the cardioprotective potential of the hydroalcoholic extract of Cinnamomum zeylanicum barks (HECZ) against isoproterenol (ISO) induced cardiotoxicity. Methods: Rats were pre-treated with HECZ (200 - 400 mg/kg, p.o.) or 100 mg/kg of vitamin E for 28 consecutive days, followed by ISO administration (85 mg/kg, s.c.) on days 29 and 30. Hemodynamic, hematological, biochemical, and histological parameters were assessed. Results: Administration of ISO resulted in significant reductions in blood pressure and cardiac antioxidant enzyme activities, along with increased leukocyte counts, enhanced lipid peroxidation, and marked alterations in cardiac marker enzyme levels. This was accompanied by an elevated heart rate, altered serum lipid profiles, increased levels of IL-6, TNF-α, and IL-1β. Histopathological analysis revealed death of heart cells and inflammation in the ISO group. However, pre-treatment with HECZ or Vitamin E significantly mitigated these ISO-induced alterations. The histopathological findings corroborated the biochemical results. Conclusion: These findings indicate that HECZ mitigated myocardial injury in ISO-treated rats, showcasing its cardioprotective effects through modulation of cardiac parameters, and its antioxidant and anti-inflammatory properties.