Publications scientifiques
Christian Fusi Suh
Autres affiliations : University of Buea
Faustin Pascal Tsagué Manfo* (Auteur correspondant)
Autres affiliations : University of Buea
Fidelis Cho‐Ngwa
Autres affiliations : University of Buea · University of Bamenda
Edouard Akono Nantia
Ndie Ngalame Dionysius
Jude Nkeng Fombele
Daisy Lum Suh
Etienne Philémon Atabonkeng
Drug and Chemical Toxicology
The use of agrochemicals as plant growth regulators, pesticides, and soil fertilizers can result in insults among farmers and other non-targeted organisms. The adverse effects of agrochemicals are of global concern, though limited studies have delineated their toxicity on blood cells and inflammatory parameters in Fako division in Cameroon. This study examined the impact of occupational exposure on haematological and inflammatory parameters among farmers in Fako division. Briefly, 165 farmers who occupationally applied agrochemicals and a reference population of 75 non-farmers were interviewed on types of agrochemicals used, knowledge and safety during use of agrochemicals, as well as related symptoms of exposure. Serum cholinesterase (acetylcholinesterase and butyrylcholinesterase) activities were measured as biomarkers of exposure to agrochemicals. Complete blood count and serum levels of interleukin-6 (IL-6) and nitric oxide (NO) were determined as haematological and inflammatory biomarkers. Results disclosed frequent use of insecticides, fungicides, herbicides and fertilizers with neglect of personal protective equipment. Reported symptoms of exposure to agrochemicals were consistent with decrease in cholinesterase activities. Exposure to agrochemicals decreased erythrocyte count and red cell distribution width, as well as increased mean cell volume, mean corpuscular hemoglobin, serum levels of NO and IL-6 in farmers; suggesting anemia and increased cellular inflammation. In conclusion, the use of agrochemicals resulted in inhibited cholinesterase activities, induced anemia, and promoted cell inflammation in farmers. These findings call for more sensitization and training of the farmers to minimize agrochemical exposure and related health hazards.
