Publications scientifiques
Nadine-Phalone Tinguep Tchapnda
Ruth Bibiane Njinkou Njambouo
Marguerite Hortence Tchuendem Kenmogne* (Auteur correspondant)
Pascal Djimeli Douanla
Turibio Kuiate Tabopda* (Auteur correspondant)
Autres affiliations : Yamagata University
Yoshihito Shiono
Natural Product Research
A new triterpene, aculeastrumone A (1), a new triterpene saponin aculeastrumoside A (2), and eleven known compounds (3–13) were isolated from MeOH/Water (80/20) extract of the fruits of Solanum aculeastrum (Solanaceae). Their structures were established by detailed 1D and 2D NMR spectroscopic studies and mass spectrometry. The isolated compounds were evaluated against three human cancer cells ((MCF-7 (breast cancer), NCI-H460 (lung cancer), and Hela (cervical cancer)) and normal human fibroblast (BJ) cell lines. Among them, saponins 2–5, 7–8, and Carpesterol 10 possess significant cytotoxic activity with IC50 ≤ 10 µM against the three cancer cell lines.
