Publications scientifiques
Séfirin Djiogue
Autres affiliations : National Hellenic Research Foundation
Maria Halabalaki
Autres affiliations : National Hellenic Research Foundation
Xanthippi Alexi
Autres affiliations : National Hellenic Research Foundation
Dieudonné Njamen
Autres affiliations : National Hellenic Research Foundation
Zacharias Tanee Fomum
Autres affiliations : National Hellenic Research Foundation
Μichael N. Alexis
Autres affiliations : National Hellenic Research Foundation
Alexios‐Léandros Skaltsounis* (Auteur correspondant)
Autres affiliations : National Hellenic Research Foundation
Journal of Natural Products
Five new isoflavones, named 5,4'-dihydroxy-7-methoxy-3'-(3-methylbuten-2-yl)isoflavone (1), 5,2',4'-trihydroxy-7-methoxy-5'-(3-methylbuten-2-yl)isoflavone (2), 5,4'-dihydroxy-7-methoxy-3'-(3-methyl-2-hydroxybuten-3-yl)isoflavone (3), 3'-formyl-5,4'-dihydroxy-7-methoxyisoflavone (4), and 5-hydroxy-3''-hydroxy-2'',2''-dimethyldihydropyrano[5'',6'':3',4']isoflavone (5), as well as six known compounds, wighteone (6), 3'-isoprenylgenistein (7), isolupabigenin (8), alpinumisoflavone (9), erypoegin D (10), and crystacarpin (11), were isolated from Erythrina poeppigiana. The structures of the isolated compounds were elucidated on the basis of chemical and spectroscopic analysis. The affinity of these compounds for the estrogen receptors ERalpha and ERbeta was evaluated using a receptor binding assay. While isoprenyl and dimethylpyrano substituents in ring A reduced the affinity of binding to ERbeta ca. 100-fold compared to genistein, the isoprenyl substituent in ring B was better accommodated, allowing 7 to bind with ca. 10-fold lower affinity than genistein.
