Publications scientifiques
Fidèle Castro Weyepe Lah
Autres affiliations : Institut de Recherches Médicales et d’Etudes des Plantes Médicinales
Marius Balemaken Missi
Autres affiliations : University of Pretoria
Natasha October
Patrick Herve Betote Didoue
Nalova Hermia Nalova Ikome
Théodora Kopa Kowa
Gabriel A. Agbor
Alembert Tiabou Tchinda* (Auteur correspondant)
Étienne Dongo
Jean Pierre Abdou
Natural Product Communications
Mortality due to microbial diseases continues to be a major problem in many developing countries. The present study aims to evaluate the antibacterial and antioxidant activities of the ethyl acetate extract and some isolated compounds from aerial parts of Echinops gracilis. The phytochemical study resulted in the isolation of a new flavonoid derivative named apigenin-7- O-(4″-feruloyl)-β-D-glucoside (1), together with 2 known compounds: apigenin -7-O-(4″-trans- p-hydroxycinnamoyl) -β-D-glucoside (2), and apigenin -7-O-glucoside (3). Their chemical structures were determined using a combination of NMR and IR spectroscopic and MS techniques, as well as by comparison with literature data. The extract and isolates were evaluated for their antibacterial and antioxydant properties. The EtOAc extract and compounds 1 and 2 showed the ability to scavenge 2,2′-zino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS) with scavenging concentration (SC 50 ) values of 13.6 ± 0.8 µg/mL, 108.2 ± 4.3 µg/mL, and 28.5 ± 2.2 µg/mL, respectively. In addition, compound 1 displayed significant activity against Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumonia, with minimum inhibition concentration (MIC) values of 31.2, 15.6, and 31.2 µg/mL respectively.
