Publications scientifiques
Viviane Flore Kamlo Kamso* (Auteur correspondant)
Yanick Kevin Dongmo Melogmo* (Auteur correspondant)
Mariscal Brice Tchatat Tali
Darline Dize* (Auteur correspondant)
Cyrille Njampa Ngansop
Pantaléon Ambassa* (Auteur correspondant)
Judith Laure Ouete Nantchouang* (Auteur correspondant)
Fabrice Fekam Boyom* (Auteur correspondant)
Bonaventure T. Ngadjui* (Auteur correspondant)
Ghislain W. Fotso* (Auteur correspondant)
Billy Toussie Tchegnitegni
Ingrid Simo Konga* (Auteur correspondant)
Heliyon
Three new lignan glucosides, namely, justisecundosides A ( 1 ), B ( 2a ), and C ( 2b ), were isolated from the whole plant of Justicia secunda together with seven known compounds ( 3−9 ). Their structures were established based on a comprehensive analysis of HR-ESI-MS, IR, UV, and CD, in conjunction with their 1D and 2D-NMR data. A putative biogenetic pathway of compounds 1−2a,b from coniferyl alcohol was proposed. In addition, the antimicrobial activities of the extract, fractions, and some isolated compounds were assessed against multiresistant bacterial and fungal strains. Furthermore, the antiplasmodial, antileishmanial, and antitrypanosomal activities were assessed against the sensitive (3D7) and multidrug-resistant (Dd2) strains of P. falciparum , promastigote and bloodstream forms of L. donovani , and Trypanosoma brucei , respectively. Compound 4 exhibited moderate antibacterial activity against Staphylococcus aureus SA RN 46003 with a MIC value of 62.5 μg/mL. Besides, compound 6 demonstrated a very good activity against sensitive (IC 50 Pf 3D7: 0.81 μg/mL) and multidrug-resistant (IC 50 Pf Dd2: 14.61 μg/mL) strains of P. falciparum while compound 4 displayed good antitrypanosomal activity (IC 50 : 1.19 μg/mL). Also, compound 1 was the most active on the promastigote form of L. donovani with an IC 50 of 13.02 μg/mL.
