Publications scientifiques
2010Article de revueanglais
Cameroonemide A: a new ceramide from Helichrysum cameroonense (ouvre dans un nouvel onglet)
Auteurs
Université de Yaoundé I
Kakam Zanetsie Antoine
Siméon F. Kouam
Vérification de la session…
Publications scientifiques
Kakam Zanetsie Antoine
Siméon F. Kouam
Hidayat Hussain* (Auteur correspondant)
Karsten Krohn
Barbara Schulz
Journal of Asian Natural Products Research
From the extracts of all parts of the plant Helichrysum cameroonense, five compounds were isolated and identified. One of them, a ceramide, named cameroonemide A (1), is reported for the first time as a new natural product. Its structure was determined by comprehensive analyses of their 1D and 2D NMR and HR-EI-MS spectral data. The remaining four known compounds were identified by comparing their spectroscopic data with those reported in the literature as kaurenoic acid (2), 3-acetyloxykaurenoic acid (3), beta-sitosterol (4), and beta-sitosterol glucopyranoside (5). Preliminary studies showed that 3-acetyloxykaurenoic acid (3) inhibited the alga Chlorella fusca, while kaurenoic acid (2) showed strong antibacterial activity against Bacillus megaterium.