Publications scientifiques
* (Auteur correspondant)
Zacharias T. Fomum
Laure B. Kouitcheu Mabeku
Jules Roger Kuiaté
Alembert Tiabou Tchinda
International Journal of Chemistry
Phytochemical screening was performed on the roots of Picralima nitida, resulting in the isolation of three new coumestan glycosides, 3-hydroxy-9-methoxy-2-[2’(E)-3’-methyl-4’-O-?-D-galactopyranosylbutenyl]-8- isoprenylcoumestan (1), 3-hydroxy-9-methoxy-2-[2’(E)-3’-methyl-4’-O-?-D-glucopyranosylbutenyl]-8-[2”(E) -3”-methyl-4”-oxobutenyl]coumestan (2), and 3-hydroxy-9-methoxy-4-[2’(E)-3’-methyl-4’-O-?-D- glucopyranosylbutenyl]-8-[2”(E)-3”-methyl-4”-oxobutenyl]coumestan (3). Acid hydrolysis of 1, 2 and 3 afforded three new coumestan, 3-hydroxy-9-methoxy-2-[2’(E)-4’-hydroxy-3’-methylbutenyl]-8- isoprenylcoumestan (4), 3- hydroxy-9-methoxy-2-[2’(E)-4’-hydroxy-3’-methylbutenyl]-8-[2”(E)-3”-methyl-4”- oxobutenyl]coumestan (5), and 3-hydroxy-9-methoxy-4-[2’(E)-4’-hydroxy-3’-methylbutenyl]-8-[2”(E)-3”- methyl-4”-oxobutenyl]coumestan (6), respectively. Structures of these compounds were elucidated on the basis of spectroscopic data and chemical transformations. Compounds 1 - 6 showed antimicrobial activities against Escherichia coli, Staphylococcus aureus, and Proteus vulgaris.
