Publications scientifiques
Bonaventure T. Ngadjui
Turibio Kuiate Tabopda
Autres affiliations : Laboratoire de Chimie Organique
Jiawei Liu
Autres affiliations : Laboratoire de Chimie Organique
Bang Luu
Autres affiliations : Laboratoire de Chimie Organique
Planta Medica
Activity-guided fractionation of root and leaf extracts from Elephantopus mollis led to the isolation of a new triterpene (1) and a new sesquiterpene lactone (2) together with five known sesquiterpene lactones (3-7). The structures of compounds 1 and 2 were determined based on their spectroscopic data. The cytotoxic activity of the isolated compounds was evaluated against neuroblastoma B104 cells. The sesquiterpene lactone-type compounds 2-7 were highly cytotoxic. Among these, compound (5) was the most cytotoxic and induced apoptosis of neuroblastoma B104 cells in a dose- and time-dependent manner. No significant difference was observed for cytotoxicity of compound 5 towards all 3 cell lines tested.
