Publications scientifiques
Didier Forest Kouganou Djossu
Joseph Tsemeugne* (Auteur correspondant)
Paul Etoga Mbarga
Armelle Tontsa Tsamo
Valérie Tedjon Sielinou
Autres affiliations : University of Johannesburg
Augustin Ephrem Nkengfack
Jean‐De‐Dieu Tamokou
Germaine Takongmo Matsuete
Emmanuel Sopbué Fondjo
Edwin M. Mmutlane
Dieter Schollmeyer
Future Medicinal Chemistry
AIM: The reactions of various heterocyclic primary amines with sulfonyl chloride derivatives or with sulfosalicylic acid results in the first case to the formation of sulfonamide derivatives and in the second case to the formation of sulfonate organic salts which are both hybrid molecule that integrate multiple pharmacophores into a single scaffold. MATERIALS AND METHODS: The novel sulfonamide derivatives 3 were obtained through mono-nucleophilic addition reactions of the corresponding primary amines to the appropriate sulfonyl derivative. In contrast, the sulfonate organic salts 5, 7 and 8 were formed as the result of an acid-base neutralization reaction, during which a molecule of amine captures the acid proton from the sulfosalicylic acid molecule. The antioxidant activity of the synthesized compounds is evaluated by determining their DPPH (2,2-Diphenyl-1-picrylhydrazyl) free radical scavenging activity as well as gallic acid equivalent antioxidant capacity (GEAC). RESULTS AND CONCLUSION: C-NMR (Carbon-13 nuclear magnetic resonance) and HRMS (High-Resolution Mass Spectrometry) spectroscopic data. Organic salt 7a was characterized by single-crystal and X-ray diffraction. Organic sulfonate salts were found to be more active than covalent sulfonamide derivatives.
