Publications scientifiques
Lazare Sidjui Sidjui
Rufin Marie Kouipou Toghueo
Elisabeth Menkem Zeu
Gaëtan Herbette
Évelyne Ollivier
Autres affiliations : Ministry of Scientific Research and Innovation · Institut de Recherches Médicales et d’Etudes des Plantes Médicinales · Laboratoire de Synthèse Organique
Cedric Derick Jiatsa Mbouna
Fabrice Fekam Boyom
Valérie M. Leddet
Pharmacologia
Background: Plants of the genus Jacaranda and Kigelia (Bignoniaceae) are traditionally used to relieve ear infection, abscesses, ulcers, diarrhea, dysentery, boils, fungal infections, psoriasis and eczema. The main objective was to undergone the phytochemical investigation and antibacterial activity of the stem barks of Jacaranda mimosifolia and Kigelia africana. Materials and Methods: Plants were extracted by solvents of various polarities. Compounds isolation was carried out using chromatography methods (medium and high-pressure liquid chromatography, open column and thin-layer chromatography). The isolated compounds were identified and characterized by using 1D and 2D NMR spectroscopy. The antimicrobial activity was assayed against some Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi) and Gram-positive bacteria (Staphylococcus aureus) by determining the Minimum Inhibitory Concentration (MIC). Results: The phytochemical investigation of Jacaranda mimosifolia and Kigelia africana led to the isolation of seventeen known compounds, seven terpenoid, four quinone and seven order compounds. The extracts and pure compounds exhibited antibacterial activities with inhibition zone diameters ranging from 0.00.0 to 11.00.2 mm. Selected crude extracts, fractions and compounds showed Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) ranging from 0.10.0 to >0.830.00 and 0.830.00 to >0.830.00 mg mLG 1 , respectively, against the tested microorganisms. Compound 17showed the best MIC against the four strains. Conclusion: The results obtained indicate that these plants could be a possible source of an effective antibacterial and justify the traditional uses.
