Scientific publications
2013Journal articleEnglishOpen access
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Scientific publications
Bilanda Danielle Claude
Andomo Mewo
Yannic Désiré
Dzeufiet Djomeni
Paul Désiré
Azebaze Anatole
Guy Blaise
Pièrre Kamtchouing
This study was designed to evaluate the antihypertensive effect of Alllanblackia gabonensis (A. gabonensis) methanol stem bark extract, and its antioxidative activity in sucrose-induced hypertensive rats. After 6-week treatment period, sucrose significantly increased systolic blood pressure as well as heart rate compare to control. A. gabonensis treatment (150 and 300 mg/kg) prevented the rise in blood pressure in rats with a significant effect on hearth rate. Sucrose induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), with no effect on total protein. In heart, liver and kidney, there was an increased in malondialdehy de (MDA) and superoxide dismutase (SOD) with a reduction of glutathione reduced (GSH). Treatment of rats with the plant extract significantly (P<0.05) prevented the altered serum and antioxidant marker levels to near normal as compared to sucrose-treated rats. The activity of the extract was comparable to the standard drug, nifedipin (5 mg/kg).These findings suggest that the modulatory influence of the methanol stem bark extract of A. gabonensis on the oxidant status might be a relevant effect accounting for its antihypertensive properties against chronic sucrose-induced hypertensive rats.