Scientific publications
2007Journal articleEnglishOpen access
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Scientific publications
Dagobert Tazoo
Oben Enyong Julius
Summary Investigation of the effect of administration of aerial part of Laportea ovalifolia extracts (aqueous, and methanol/methylenechloride ) on blood glucose levels was evaluated in this study in normal and alloxan diabetic rats. The qualitative phytochemical screening of these extracts was carried out. It revealed the presence of compounds such as saponins, phenols compounds and sugars in the both extracts. Among the two extracts, aqueous extract at the dose of 200 mg/kg body weight exhibited a significant antihyperglycaemia activity (P<0.001) in the reduction of blood glucose levels 5h after treatment of alloxan diabetic rats. The same dose did not cause any hypoglycaemic activity in normal rats. The results were compared with the diabetic rats treated with tolbutamide which was better. Oral administration of these extracts at the dose of 200 mg/kg produce a significant antihyperglycaemia effect in hyperglycaemic rats. This support the application of Laportea ovalifolia as an antihyperglycaemic agent.