Scientific publications
Gisèle A Kiki Gisèle
Désirè Djomeni Dzeufiet
Harquin Simplice Foyet
Paulin Nana
Célestin Dogmo Sokeng
P. Kamtchouing
Journal of Physiology and Pharmacology Advances
The present study has been undertaken to assess the analgesic and the anti-inflammatory properties of methanolic extract Dichrostachys glomerata fruit. Pain was induced in mice by the intraperitoneal administration of 1 % acetic acid, and formalin. Carrageenan and histamin (1%) were used to induce inflammation in rat paws. At the doses of 25 and 50 mg/kg, D. glomerata significantly inhibited pain induced by acetic acid with a percentage inhibition of 80.0 and 76.0 %, respectively. The neurogenic pain induced by formalin was significantly inhibited by the plant extract at the doses of 25 and 50 mg/kg (56.14 and 61.46% inhibition respectively) while the inflammatory phase was significantly inhibited at all the doses tested. The extract (25 mg/kg) significantly reduced oedema induced by carrageenan with 79.85 % inhibition at after 30 minutes while the oedema induced by the serotonin was also significantly inhibited the plant extract.
