Scientific publications
Guy Roland Ebede
Other affiliations: University of Karachi · International Center for Chemical and Biological Sciences
Dieudonné Emmanuel Pegnyemb
Joseph Thierry Ndongo* (Corresponding author)
Emeka Emea Okoro
Patrick Hervé Diboue Betote
M. Iqbal Choudhary
Other affiliations: International Center for Chemical and Biological Sciences
Xavier Siwe‐Noundou* (Corresponding author)
Scientific Reports
Sorindeia nitidula (Anacardiaceae) is used by traditional practitioners to treat influenza illnesses with cephalgia and febrile aches. However, the potential active ingredients for its remarkable antioxidant, anti-HIV and antitrypanosomal activities remain unexplored. The present study aims to evaluate the antioxidant, anti-HIV and antitrypanosomal activities of the ethyl acetate extract of S. nitidula (SN) in order to screen out the bioactive compounds and to analyze their possible mechanisms of action. Overall, 21 phenolic compounds were annotated, by using the MS and MS/MS information provided by the QTOF-MS. In vitro assays on the extract revealed potent antioxidant (IC 50 = 0.0129 ± 0.0001 mg/mL), anti-HIV (IC 50 = 1.736 ± 0.036 µM), antitrypanosomal (IC 50 = 1.040 ± 0.010 µM) activities. Furthermore, SN did not present cytotoxic effect on HeLa cancer cell lines. The integrated strategy based on LC-ESI-QTOF-MS/MS provided a powerful tool and a multidimensional perspective for further exploration of active ingredients in S. nitidula responsible for the antioxidant, anti-HIV and antitrypanosomal activities.
