Scientific publications
Brice Mittérant Mba’ning* (Corresponding author)
Bruno Lenta Ndjakou* (Corresponding author)
Etienne Tsamo
Ferdinand Mouafo Talontsi
Alain Méli Lannang
Norbert Sewald
Birger Dittrich
Hartmut Laatsch
Zeitschrift für Naturforschung B
Abstract A mixture of two compounds with potent antiplasmodial activity in vitro against the W2 strain of Plasmodium falciparum (half maximal inhibitory concentration, 1.12 μg/mL) was obtained in a previous investigation of the CH 2 Cl 2 -MeOH extract of the seeds of Salacia longipes var. camerunensis. Separation by column chromatography led now to the isolation of salaterpene E ( 1 ) and (1 R ,2 R ,4 S ,5 S ,6 R ,7 R ,9 S ,10 R )-2-acetoxy-1,6,9-tribenzoyloxy-4-hydroxy-dihydro- β -agarofuran ( 2 ). The structure of 1 was elucidated by spectroscopic analysis, and its absolute configuration was established unambiguously by means of single-crystal X-ray diffraction. Also the absolute configurations of the recently described salaterpenes A ( 2a ) and D ( 2b ) were determined by this method using the anomalous scattering of the oxygen atoms only.
