Scientific publications
Alessandro Venditti
Other affiliations: University of Maroua
Moïse Diguir
Bernard Dabole* (Corresponding author)
Isaac Silvère Gade
Peron Bosco Leutcha
Honore Wangso
Matthieu Matcheme
Albert Atangana Fouda
Jean Noël Nyemb
Moussa Djaouda
Benoît Koubala Bargui
Natural Product Research
The present work investigates the phytochemical study and the antibacterial and antioxidant activities of Kigelia africana (Lam.) Benth. Column chromatography separation on silica gel of fractions led to the isolation of a new limonoid derivative named digsecokigelianolide (1), as well as nine known compounds (2-10). The structures of the isolated compounds were determined by comprehensive spectroscopic analysis, including 1 & 2D NMR, IR, UV, mass spectrometry and comparison with previous reported data. Compound 1 showed moderate antiradical activity (IC50 = 181.12 µg/mL) against ABST•+ radical compared to BHT (159.48 µg/mL) used as standard, and a good antibacterial activity against Salmonella typhi (MIC: 22.0 mm), Escherichia coli (MIC: 15.0 mm) and Pseudomonas aeruginosa (MIC: 20 mm) at the concentration of 25 mg/mL. Compound 9 and 10 showed good antiradical (which ranges from 56.39 to 61.16% of inhibition) and antibacterial (which ranges from 12 to 20 mm of inhibition zone) activities.
