Scientific publications
Marie G. Tsepeupon Matchide
Yves Martial Mba Nguekeu
Elodie Gaële Matheuda
Josker Nghokeng
Gaétan Tchangou Tabakam
Raymonde A. Dzatie Djoumbissie
Silvère Augustin Ngouela
Mathieu Téné
Maurice Ducret Awouafack* (Corresponding author)
Saw Yu Yu Hnin
Yuan‐E Lee
Hiroyuki Morita* (Corresponding author)
Chemistry & Biodiversity
Abstract A new fructofuranoside glycerol, dryoptkirbioside ( 1 ), along with thirteen known compounds ( 2 ‐ 14 ), was isolated from the MeOH extract of Dryopteris kirbi rhizomes by silica gel column chromatography, Sephadex LH‐20 column chromatography, and semipreparative HPLC. The structure of the new compound was determined by analyses of its spectroscopic data including nuclear magnetic resonance (NMR), and high‐resolution electrospray ionisation mass spectrometry (HR‐ESI‐MS) and chemical conversions. The hexane‐soluble portion and the EAF A fraction showed strong activities against lung (A549), breast (MCF‐7), and cervical (HeLa) human cancer cell lines (IC 50 values ranging from 4.0 to 8.8 μg/mL). Aspidinol P ( 5 ) and aspidinol B ( 6 ) exhibited moderate to low cytotoxicity on the three cell lines (IC 50 values ranging from 20.4 to 58.7 μM). The MeOH extract and hexane‐soluble portion had excellent activities against Staphylococcus aureus and Bacillus subtilis (MICs 11.7 and 23.4 μg/mL), whereas the AcOEt‐ and BuOH‐soluble portions were significantly active on S. aureus (MICs 46.9 and 93.8 μg/mL). The main fractions EAF B , EAF C and nBF B displayed excellent activity against S. aureus (MICs 11.7 and 23.4 μg/mL). Aspidinol B ( 6 ) had significant activity, while aspidinol P ( 5 ) was moderately active against S. aureus and B. subtilis (MICs 42.0 and 89.5 μM).
