Antidiabetic and Wound Healing Effects of Smeathxanthone A (opens in a new tab)

Authors

University of Yaoundé I

University of Maroua

David Emery Tsala

Alain Méli Lannang

Jean Arnaud Ekanga

Blandine Mbougen Guemmogne

University of Greenwich

Solomon Habtemariam

Bielefeld University

Norbert Sewald

Recent Advances in Biology and Medicine

Abstract

The purpose of this study was to investigate whether smeathxanthone A isolated from G arcinia smeathmanii improves incisional wound healing in diabetic mice. Male albino alloxan-induced diabetic mice ( n = 20) were divided into five groups: normal control, diabetic control, 2.5 mg/kg glibenclamide given orally, 0.05 and 0.1 mg/kg smeathxanthone A given subcutaneously. Animals were euthanized on postoperative day 10 after wounding; body weight, blood glucose, breaking strength, and histologic examination were reviewed. Smeathxanthone A significantly increased skin tensile strength (24% higher than diabetic control group when given at 0.1 mg/kg), stimulated hair growth, and reduced signs of inflammation in the scar sections. Smeathxanthone A also reduced blood glucose levels in diabetic mice (45% higher than diabetic control group when given at 0.1 mg/kg). The present study demonstrates that administration of smeathxanthone A after laparotomy expedites wound healing in mice. We suggest that it could confer benefits to tissue healing by significantly enhancing tissue collagen deposition and controlling blood glucose levels.

Keywords

Théophile Dimo