Scientific publications
2006Journal articleEnglish
Antimalarial and antitrypanosomal activities of West Cameroon medicinal plants (opens in a new tab)
Authors
University of Yaoundé I
BL Ndjakou
Ferdinand Tantangmo
Etienne Tsamo
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Scientific publications
BL Ndjakou
Ferdinand Tantangmo
Etienne Tsamo
Bruce G. Weniger
Mehdi Chaabi
Robert Anton
Planta Medica
Fourteen extracts from seven Cameroon medicinal plants [1, 2], traditionally used to treat malaria and other parasitic diseases were screened for their antiprotozoal activities against Plasmodium falciparum K1 chloroquine resistant strain and Trypanosoma brucei rhodesiense , protozoa responsible for malaria and trypanosomiasis, respectively. The most active extract against P. falciparum was the methanolic extract of Albizia zygia stembark, with an IC 50 value of 1.04µg/mL. Three of the tested extract showed IC 50 below 7.15µg/mL against T.b. rhodesiense , with Albizia zygia methanolic extract showing again the best activity (IC 50 =0.18µg/mL). These results contribute to the validation of the traditional antiprotozoal use of these medicinal species in Cameroon. References : 1. Vivien J., Flaure J.J. (1973), Arbres des forêts denses d'afrique centrale: Espèces du Cameroun. République Francaise. Agence de coopération culturelle et technique. 2. Laird S.A. et al. (1997), Medicinal Plants of the Limbe Botanic Garden, Cameroon.