Scientific publications
Béatrice Dambaya Ounzia
Georges Této
Marcel Tongo
Laure Lemee
Elise Elong Lobè
Charlotte Tangimpundu
Guy Benoit Lekeufack
Céline Nguefeu Nkenfou
Vittorio Colizzi
Simon Eyongabane Ako
Alexis Ndjolo
Fortune Journal of Health Sciences
Background: Children with HIV continue to be at a higher risk of non-communicable diseases (NCDs), even with improvements in the treatment of prenatal exposure to HIV-1 infection. This study aimed to identify genetic variations associated with HIV-1 and their potential influence on the risk of NCDs in offspring exposed during pregnancy. Methods: We conduct a genome-wide association study (GWAS) on a cohort of 689 participants from Cameroon, employing a case-control design and a genomic epidemiology approach. Of these, 421 were HIV-infected and 268 were not. Single nucleotide polymorphisms (SNPs) were performed using Illumina BeadChips. Results: Twenty SNPs in all were found, and the majority of the alterations were silent or synonymous. Those linked to HIV rapid progression include rs1422884 (GRIA1, Chr5) and exm665143 (TRPV6, Chr7) 7.9x10-6, with OR = 0.01, rs4915847 (C1orf87, Chr1), rs7578597, and exm189601 (THADA, Chr 2). The NCD-related SNPs rs1693687 (Chr10) 8.4x10-7 with OD=0.04 and rs7175885 (Chr15) showed significant associations with slow progression in HIV-infected individuals: THADA (rs7578597, exm189601, Chr2) was linked to type 2 diabetes and metabolic disorders. Both TENM2 (rs10057680, Chr5) and RBFOX1 (rs9302839, Chr16) have been associated with neurocognitive impairment. rs1693687 (Chr10) and rs10231785 (Chr7) were linked to cardiovascular diseases (CVDs). PHLPP1 (rs692916, Chr18) and ZNF208 (rs10426971, Chr19) have been connected to cancer risk and immune response. Conclusion: The genetic variations linked to protective effects against HIV-1's rapid development as well as other variants with possible genetic resistance mechanisms are highlighted in this work. Additionally, several SNPs overlap with risk factors for NCDs, indicating that there may be common genetic processes. These results highlight the value of precision medicine strategies in HIV care.
