Scientific publications
Tchebemou Bakang Bruno
* (Corresponding author)
Emmanuel Mouafo Tekwu
Other affiliations: University Teaching Hospital of Yaounde
Soh Desire
Yves Oscar
Kerstin Andrea-Marobela
Nkwengoua Tchouboun
Nganso Yves Oscar Ditchou
International Journal of Pharmaceutical Sciences Review and Research
Phytochemical composition of roots and leaves of Faidherbia albida, let to the isolation and the identification of fourteen ( The structures of all the isolated constituents were determined by a comprehensive use of spectroscopic analysis such as 1D-and 2D-NMR, EI-MS, and ESI-MS coupled with the comparison of data thereof obtained with those of known analogs listed in the literature. These compounds and various extracts, fractions were investigated for their antioxidant potential, and antischistosomal and antifungal effects against Schistosoma mansoni and Candida albicans respectively, -Glucosidal and Trypsin activity. The results revealed that all the extracts (roots and leaves), exhibited antifungal, antioxidant and enzyme -Glucosidase inhibition activities. Moreover, Quercetin-3-O--rhamnoside (13) inhibited -Glucosidase, Trypsin and Schistosoma mansoni. The synergic effect of the extract and fraction, and also their triple of Quercetin-3-O--rhamnoside (13) could classified Faidherbia albida among the potential candidate for the development of multitarget drugs. This could reduce the combination of multiple biological active agent (multitherapy) therapy in favor of multitarget drug strategies.
