Scientific publications
Armelle Tontsa Tsamo* (Corresponding author)
Edwige P. Fodja Saah
Augustin Ephrem Nkengfack
Moses K. Langat
Other affiliations: University of Surrey
Alain François Kamdem Waffo
Zeitschrift für Naturforschung B
Abstract Chemical investigation of the roots of Trichilia welwitschii yielded a cycloartane type terpenoid 28,29-bis-norcycloart-24-en-3 β ,4 α ,6 α -triol ( 1 ), isolated as pure compound for the first time, three coumarins and three sterols. New cycloartane derivatives ( 1a ) and ( 1b + 1c ) were obtained by hemi-synthetic reaction of compound 1 . The structures of 1a – c were established by spectroscopic methods including 1D and 2D-NMR analysis, HR-EIMS, chemical transformations and by comparison of these data with those of related compounds. Evaluated for their antimycobacterial potential, compound 1 and 1b + 1c were determined to show significant activities against Mycobacterium tuberculosis MIC values of 6.25 μg mL −1 while compound 1a displayed weak activity showing MIC > 100 μg mL −1 . Compounds 2 – 4 displayed moderate activity with MIC values range from 12.5 to 50 μg mL −1 .
